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Our Research Group

A Multifaceted Approach

At the Amplified Molecular Sensors Lab, we aim to develop integrated microsystems that enable new applications not possible before. Using a systems approach, we are applying fundamentals of physics, chemistry, and engineering to solve problems relevant to today’s critical biomedical applications. In particular, we emphasize the use of amplification strategies to add orders of magnitude improvement to chemical and biomolecular sensing, while at the same time improving the simplicity and usability of the technology. Contact Dr. White or take a look at our most recent publications.

Projects

Inkjet-Printed SERS Substrates

Inkjet-Printed SERS Substrates

As a bio/chemical sensing technique, surface enhanced Raman spectroscopy (SERS) offers sensitivity comparable to that of fluorescence detection while providing highly specific information about the analyte. Although single molecule identification with SERS was demonstrated over a decade ago, today a need exists to develop practical solutions for point-of-sample and point-of-care SERS systems. We recently demonstrated the fabrication of SERS substrates by inkjet printing silver and gold nanostructures onto paper and other similar membranes, achieving detection limits comparable to conventional nanofabricated substrates. Furthermore, we have leveraged the fluidic properties of paper to enhance the performance of the SERS devices while also enabling unprecedented ease of use, which is critical for extending chemical and biological analytics from central labs out into the field. We are currently investigating the use of these paper-based SERS sensors for both chemical and biological sensing applications.

  • Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Multiplex detection of DNA targets using polymerase chain reaction (PCR) and paper surface enhanced Raman spectroscopy (SERS) chromatography, Applied Spectroscopy, 68, 909-915, 2014. DOI:10.1366/14-07451.

  • Jordan F. Betz, Wei W. Yu, Yi Cheng, Ian M. White, and Gary W. Rubloff, Simple SERS substrates: powerful, portable, and full of potential, Physical Chemistry Chemical Physics, 16, 2224-2239, 2014. DOI:10.1039/C3CP53560F.

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Inkjet-printed fluidic paper devices for chemical and biological analytics using surface enhanced Raman spectroscopy, Journal of Selected Topics in Quantum Electronics, 20, 7300510, 2014. DOI:10.1109/JSTQE.2013.2286076.

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Highly sensitive and flexible inkjet printed SERS sensors on paper, Methods, 63, 219-224, 2013. DOI:10.1016/j.ymeth.2013.07.010.

  • Wei W. Yu and Ian M. White, Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates, Analyst, 138, 3679-3686 2013. DOI:10.1039/C3AN00673E.

  • Wei W. Yu and Ian M. White, Inkjet-Printed Paper-Based SERS Dipsticks and Swabs for Trace Chemical Detection, Analyst, 138, 1020-1025, 2013. DOI:10.1039/C2AN36116G. (outside front cover)

  • Wei W. Yu and Ian M. White, A simple filter-based approach to surface enhanced Raman spectroscopy for trace chemical detection, Analyst, 137, 168-173, 2012. DOI:10.1039/C2AN15947C.

  • Wei W. Yu and Ian M. White, Inkjet Printed Surface Enhanced Raman Spectroscopy Array on Cellulose Paper, Analytical Chemistry 82, 9626-9630, 2010. DOI:10.1021/ac102475k.

PCR Sample Prep for the Point-of-Care

PCR Sample Prep for the Point-of-Care

We have invented a process that dramatically reduces the hands-on time and complexity of PCR sample preparation. This may be the key factor that finally enables PCR-based molecular diagnostics to be utilized in near-patient applications.

  • Imaly A. Nanayakkara, Weidong Cao, and Ian M. White, Simplifying nucleic acid amplification from whole blood with direct PCR on chitosan microparticles, Analytical Chemistry, 89, 3773–3779, 2017 DOI:10.1021/acs.analchem.7b00274

  • Kunal R. Pandit, Imaly A. Nanayakkara, Weidong Cao, Srinivasa R. Raghavan, and Ian M. White, Capture and direct amplification of DNA on chitosan microparticles in a single PCR-optimal solution, Analytical Chemistry, 87, 11022-11029, 2015. DOI:10.1021/acs.analchem.5b03006

Functional Nucleic Acids for Biosensing

Functional Nucleic Acids for Biosensing

We utilize aptamers and catalytic nucleic acids as biorecognition and reporter elements in biosensor systems. We have invented an exponentially amplified photocatalyzed reaction that enables sensitive, naked-eye detection of hemin-binding, HRP-mimicking DNAzymes ("peroxidymes") with a dynamic range of five orders of magnitude. This reaction,PARCR, will facilitate use of peroxidymes as reporters in point-of-care assays by simplifying detection and minimizing manual steps.

  • John P. Goertz and Ian M. White, Peroxidyme-Amplified Radical Chain Reaction (PARCR): Visible Detection of a Catalytic Reporter, Angewandte Chemie, 56, 13411–13415, 2017. DOI:10.1002/anie.201706163.

Rapid Phenotypic Detection of Antibiotic Resistance

Rapid Phenotypic Detection of Antibiotic Resistance

Publications in progress...

Next-Generation Rolling Circle Amplification

Next-Generation Rolling Circle Amplification

Publications in progress...

People

Our Lab

White Lab 2016

Our Principal Investigator

Dr. Ian White

Dr. Ian White

Associate Chair and Director of Undergraduate Studies
Fischell Department of Bioengineering
2216 Jeong H. Kim Engineering Bldg.
University of Maryland
College Park, MD 20742
301-405-6230
Google Scholar


Joined the University of Maryland in 2008
Post-doc: University of Missouri, Life Sciences Center (2005–2008)
Ph.D. Electrical Engineering, Stanford University (2002)

Our Graduate Students

John Goertz

John Goertz

LinkedIn | Google Scholar |

Bio:

  • Fischell Fellow, Future Faculty Fellow
  • Joined White Lab in 2014
  • B.S. in Physics and Cell & Molecular Biology, Seattle University (2013)

White Lab Publications

  • John P. Goertz and Ian M. White, Peroxidyme-Amplified Radical Chain Reaction (PARCR): Visible Detection of a Catalytic Reporter, Angewandte Chemie, 56, 13411–13415, 2017. DOI:10.1002/anie.201706163.
Imaly Nanayakkara

Imaly Nanayakkara

LinkedIn |

Bio:

  • Joined White Lab in 2015
  • M.S. in Biomedical Engineering, Univerity of California - Irvine (2014)
  • B.S. in Biomedical Engineering, Boston University (2012)

White Lab Publications:

  • Imaly A. Nanayakkara, Weidong Cao, and Ian M. White, Simplifying nucleic acid amplification from whole blood with direct PCR on chitosan microparticles, Analytical Chemistry, 89, 3773–3779, 2017 DOI:10.1021/acs.analchem.7b00274
  • Kunal R. Pandit, Imaly A. Nanayakkara, Weidong Cao, Srinivasa R. Raghavan, and Ian M. White, Capture and direct amplification of DNA on chitosan microparticles in a single PCR-optimal solution, Analytical Chemistry, 87, 11022-11029, 2015. DOI:10.1021/acs.analchem.5b03006
Hieu Nguyen

Hieu Nguyen

LinkedIn |

Bio:

  • NSF Fellow
  • Joined White Lab in 2015
  • B.A. in Biology, Brown University (2009)
Alessandra Zimmermann

Alessandra Zimmermann

LinkedIn |

Bio:

  • Joined White Lab in 2015
  • B.S. in Chemistry with Biology minor, Carnegie Mellon (2013)

Our Undergraduate Students

Kenya Colvin

Kenya Colvin

LinkedIn |

Bio:

  • McNair Scholar, LSAMP Fellow, ASPIRE Fellow
  • Joined White Lab in 2015
  • Chemical Engineering Class of 2018
Andrew Lippe

Andrew Lippe

LinkedIn |

Bio:

  • Joined White Lab in 2017
  • Bioengineering Class of 2018
Connor Hall

Connor Hall

LinkedIn |

Bio:

  • Banneker Key Scholar
  • Joined White Lab in 2017
  • Bioengineering Class of 2020
Aliyah Taule

Aliyah Taule

LinkedIn |

Bio:

  • Dean's Scholar, B.J. Harrod Scholar
  • Joined White Lab in 2017
  • Bioengineering Class of 2020

Our Previous Lab Members

Post-Doctoral Associates

Dr. Jeffrey Burke

Dr. Jeffrey Burke

Principal Engineer at Circulomics Inc
Postdoctoral Research Associate in the White Lab, 2011-2013

Dr. I-Jane Chen

Dr. I-Jane Chen

Staff Engineer at Becton Dickonson
Former R&D Engineer, Microfluidics Team at Caliper Life Sciences
Postdoctoral Research Associate in the White Lab, 2008-2011

Graduate Students

Dr. Stephen Restaino

Dr. Stephen Restaino

LinkedIn

Bio:

  • Senior Research Engineer, Maryland Development Center
  • Doctoral Student in White Lab 2013-2017
  • Biomedical Engineer/Faculty Research Assistant, FDA/UMD, 2011-2013
  • B.S. in Engineering Science and Mechanics, Virginia Tech (2011)

White Lab Publications:

  • Doctoral Dissertation: Surface enhanced Raman Spectroscopy technologies and and techniques for on-site quantification of chemical and biological analytes
  • Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035
Qian Zhang

Qian Zhang

Visiting Doctoral Student in White Lab 2015-2016
Advised by Prof. Zhihong Nie
M.S. in Chemistry, Beijing University of Aeronautics and Astronautics
B.S. in Applied Chemistry, Beijing University of Aeronautics and Astronautics

Ken Sharp

Ken Sharp

Production Technician at Trevigen
Masters Student in the White Lab, 2015-2016

Sean Virgile

Sean Virgile

Co-founder and CFO of Diagnostic anSERS, a company utilizing technology he helped develop while in the White Lab
Doctoral Student in the White Lab, 2010-2015

Dr. Kunal Pandit

Dr. Kunal Pandit

Research Engineer at New York Genome Center
Doctoral Student in the White Lab, 2012-2015

Dr. Eric Hoppmann

Dr. Eric Hoppmann

Data Scientist at Earth Networks
Co-founder and Former CEO of Diagnostic anSERS, a company utilizing technology he helped develop while in the White Lab
Doctoral Student in the White Lab, 2008-2013

Dr. Soroush Yazdi

Dr. Soroush Yazdi

Senior Biomedical Engineer at Medtronic
Doctoral Student in the White Lab, 2009-2013

Dr. Wei "VeeMoon" Yu

Dr. Wei "VeeMoon" Yu

Co-founder and Lead Scientist of Diagnostic anSERS, a company utilizing technology he helped develop while in the White Lab
Postdoctoral Research Associate in the White Lab, 2013-2014
Doctoral Student in the White Lab, 2008-2013

Dr. Katayoon Saadin

Dr. Katayoon Saadin

Complex Microbial Systems Group at the National Institute of Standards and Technology
Former Clinical Research Associate at LifeBridge Health
Former Biotechnology Consultant for the University System of Maryland
Doctoral Student in the White Lab, 2009-2012

Undergraduate Students

Megan Dang

Adam Berger

Eden Paul

Divya Jain

Carolyn Lane

Kristen Giles

Aaron Rubinstein

Marina Shumakovich

Neerav Patel

Amanda Dols

Nathalie Dagenais

Jenni Jung

Jon Eskin

Steve Robinson

Helen Ji

Jeff Misiewicz

Ashu Poudyal

Amin Asemani

Dave Gaddes

Naomi Goldstein

Farnoosh Farahi

News

(February 9, 2018) Kenya Colvin has been awarded the ASPIRE undergraduate research fellowship to continue her research in spring 2018.

(November 13, 2017) Diagnostic anSERS, along with our paper SERS technology, has been acquired by Metrohm Raman.

(October 26, 2017) Stephen Restaino passed his Ph.D. dissertation defense! Congratulations!

(October 26, 2017) Adam Berger and Megan Dang graduate with Bachelor of Science degrees in Bioengineering. Congratulations, and good luck on your future endeavors!

(April 14, 2017) Adam Berger's thesis was selected as a winner in the 2017 Best Honors Thesis category for the Winston Family Honors Best Student Paper Awards.

(April 12, 2017) Adam Berger successfully defended his BIOE Honors Thesis.

(April 3, 2017) Imaly Nanayakkara successfully defended her Ph.D. proposal!

(February 23, 2017) Adam Berger has been named the recipient of the Fischell Outstanding Senior Award.

(February 1, 2017) Adam Berger has been named the recipient of the A. James Clark School of Engineering Dean’s Award, the most prestigious award in the college.

(August 24, 2016) Adam Berger has been named a Philip Merrill Presidential Scholar in recognition of his academic excellence.

(August 10, 2016) Adam Berger has received the BMES Undergraduate Design and Research Award for his work on therapeutic drug monitoring with paper SERS devices. The award will be presented at the 2016 BMES conference.

(April 25, 2016) Megan Dang has been awarded the SEEDS undergraduate research fellowship from summer 2016 and the 2016-2017 academic year.

(April 22, 2016) Kenya Colvin has been awarded the ASPIRE undergraduate research fellowship to continue her research in summer 2016.

(April 7, 2016) Adam Berger has been awarded the Dinah Berman Memorial Award for his combined academic excellence and service to the Clark School.

(April 7, 2016) Adam Berger has been awarded the Fischell Department of Bioengineering Outstanding Junior Award.

(April 6, 2016) Adam Berger has won a UMD HHMI summer research fellowship!

(February 4, 2016) John Goertz passed his Ph.D. proposal! Congratulations!

(August 6, 2015) Stephen Restaino passed his Ph.D. proposal! Congratulations!

(July 9, 2015) Adriel Sumathipala is selected as a regional finalist in the Google Science Fair.

(May 21, 2015) Kunal Pandit successfully defended his Ph.D. dissertation! Congratulations!

(March 31, 2015) Hieu Nguyen has been awarded the prestigious NSF Fellowship! Congratulations!

(March 13, 2015) Imaly Nanayakkara (Bioengineering Ph.D. student) and Hieu Nguyen (Bioengineering Ph.D. student) have joined our group.

(February 18, 2015) Our lab wins a MIPS award supported by the state of Maryland and Diagnostic anSERS.

(June 5, 2014) Kristen Giles passes her Bioengineering Undergraduate Honors thesis defense.

(May 14, 2014) Stephen Restaino wins the Distinguished Graduate Student Teaching Award from the University of Maryland Center for Teaching Excellence.

(March 10, 2014) Kristen Giles wins Best Undergraduate Research Poster Award at the Mid-Atlantic Micro/Nano Alliance annual symposium.

Giles Award

(January 1, 2014) John Goertz, the 2013 winner of the Fischell Fellowship, has joined the group.

Eric Hoppmann successfully defended his Ph.D. dissertation. Congratulations!

Soroush Yazdi successfully defended his Ph.D. dissertation. Congratulations!

Veemoon Yu was awarded the Fischell BIOE Outstanding Graduate Researcher for 2012-2013.

Kristen Giles has been accepted into the BIOE Honors Program.

Veemoon Yu successfully defended his Ph.D. dissertation. Congratulations!

Hoppmann wins GRID competition with presentation on paper-SERS detection of PCR products.

Virgile, Diagnostic anSERS, take third at the national Cupid's Cup Competition.

Our lab wins a MIPS award, supported by the state of Maryland and Diagnostic anSERS.

Yu's paper on inkjet-printed paper SERS dipsticks, swabs, and lateral flow concentration is selected for Analyst outside front cover.

Analyst front cover

Katayoon Saadin successfully defended her Ph.D. dissertation. Congratulations! She is the first graduate from our research group.

Hoppmann, Virgile reach finals of MTECH's $75K Business Plan Competition.

Our group wins a collaboration award from the FDA Center of Excellence in Regulatory Science and Innovation.

Our paper-based SERS devices were featured by SPIE Newsroom.

Our group wins a Blue Ocean Grant from Ocean Optics.

Sean Virgile, the 2010 winner of the Fischell Fellowship, has joined the group.

C&EN reports on Yu's ink-jet-printed SERS array.

Yu publishes first ever ink-jet-printed SERS microdevice.

SERS on paper image

Available Positions

Post-Doctoral Associates

The Amplified Molecular Sensors Lab at the University of Maryland currently has an opening for a post-doc. The selected candidate's primary project would involve the rapid detection of antimicrobial resistance using novel materials and concepts in a paper/membrane platform. The selected candidate would also be encouraged to develop her/his own research ideas as side projects in order to generate potential future projects for the candidate and the group. Current areas of interest include:

Technologies:

  • Paper-based diagnostic tools
  • Isothermal amplification
  • Novel uses of materials in sensing systems
  • Inkjet-printed surface-enhanced Raman sensors
  • Applications:

  • Culture-independent screening tools for antimicrobial resistance
  • Exosome and miRNA/mRNA detection
  • Infectious disease diagnosis
  • The selected candidate will be strongly encouraged to pursue career-enhancing fellowships. The selected candidate will also engage in proposal writing on behalf of the research group; strong writing capabilities are a must.

    Interested candidates should send a cover letter and CV to Prof. White.

    Graduate Students

    In the Fischell Department of Bioengineering, graduate students do not select research groups until the end of their first year. Therefore, if you are interested in joining our group, please first apply for admission to the department.

    Undergraduate Students

    Currently we do not have any undergraduate research positions available.

    Publications

    Peer-Reviewed Publications

    1. John P. Goertz and Ian M. White, Phase-change partitions for thermal automation of multi-step reactions, Analytical Chemistry, DOI:10.1021/acs.analchem.7b05400.

    2. Stephen M. Restaino and Ian M. White, Real-time multiplexed PCR using surface enhanced Raman spectroscopy in a thermoplastic chip, Lab on a Chip, DOI:10.1039/C7LC01227F.

    3. John P. Goertz and Ian M. White, Peroxidyme-Amplified Radical Chain Reaction (PARCR): Nested Photochemical and Biochemical Positive Feedback, Angewandte Chemie, 56, 13411–13415, 2017. DOI:10.1002/anie.201706163.

    4. Imaly A. Nanayakkara, Weidong Cao, and Ian M. White, Simplifying nucleic acid amplification from whole blood with direct PCR on chitosan microparticles, Analytical Chemistry, 89, 3773–3779, 2017. DOI:10.1021/acs.analchem.7b00274.

    5. Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035

    6. Kunal R. Pandit, Imaly A. Nanayakkara, Weidong Cao, Srinivasa R. Raghavan, and Ian M. White, Capture and direct amplification of DNA on chitosan microparticles in a single PCR-optimal solution, Analytical Chemistry, 87, 11022-11029, 2015. DOI:10.1021/acs.analchem.5b03006

    7. Kunal R. Pandit, Paul E. Rueger, Richard V. Calabrese, Srinivasa R. Raghavan, and Ian M. White, Assessment of surfactants for efficient droplet PCR in mineral oil using the pendant drop technique, Journal of Colloids and Surfaces B: Biointerfaces, 126, 489-495, 2015. DOI:10.1016/j.colsurfb.2015.01.001

    8. Jeffrey M. Burke, Kunal Pandit, John P. Goertz, and Ian M. White, Fabrication of rigid microstructures with thiol-ene-based soft lithography for continuous-flow cell lysis, Biomicrofluidics, 8, 056503, 2014. DOI:10.1063/1.4897135.

    9. Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Multiplex detection of DNA targets using polymerase chain reaction (PCR) and paper surface enhanced Raman spectroscopy (SERS) chromatography, Applied Spectroscopy, 68, 909-915, 2014. DOI:10.1366/14-07451.

    10. Jeffrey M. Burke, Rebecca E. Zubajlo, Elisabeth Smela, and Ian M. White, High-throughput particle separation and concentration using spiral inertial filtration, Biomicrofluidics, 8, 024105 2014. DOI:10.1063/1.4870399.

    11. Jordan F. Betz, Wei W. Yu, Yi Cheng, Ian M. White, and Gary W. Rubloff, Simple SERS substrates: powerful, portable, and full of potential, Physical Chemistry Chemical Physics, 16, 2224-2239, 2014. DOI:10.1039/C3CP53560F.

    12. Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Inkjet-printed fluidic paper devices for chemical and biological analytics using surface enhanced Raman spectroscopy, Journal of Selected Topics in Quantum Electronics, 20, 7300510, 2014. DOI:10.1109/JSTQE.2013.2286076.

    13. Soroush H. Yazdi, Kristen L. Giles, and Ian M. White, Multiplexed detection of DNA sequences using a competitive displacement assay in an microfluidic SERRS-based device, Analytical Chemistry, 85, 10605-10611, 2013. DOI:10.1021/ac402744z.

    14. Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Highly sensitive and flexible inkjet printed SERS sensors on paper, Methods, 63, 219-224, 2013. DOI:10.1016/j.ymeth.2013.07.010.

    15. Wei W. Yu and Ian M. White, Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates, Analyst, 138, 3679-3686 2013. DOI:10.1039/C3AN00673E.

    16. Katayoon Saadin, Jeffrey M. Burke, Neerav P. Patel, Rebecca E. Zubajlo, and Ian M. White, Enrichment of tumor-initiating breast cancer cells within a mammosphere-culture microdevice, Biomedical Microdevices, 15, 645-655, 2013. DOI:10.1007/s10544-013-9755-y.

    17. Wei W. Yu and Ian M. White, Inkjet-Printed Paper-Based SERS Dipsticks and Swabs for Trace Chemical Detection, Analyst, 138, 1020-1025, 2013. DOI:10.1039/C2AN36116G. (outside front cover)

    18. Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, in press, DOI:10.1039/C2AN36232E.

    19. Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, 138, 100-103, 2013. DOI:10.1039/C2AN36232E.

    20. Soroush H. Yazdi and Ian M. White, An Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Chemical Contaminants, Analytical Chemistry, 84, 7992-7998, 2012. DOI:10.1021/ac301747b.

    21. Katayoon Saadin and Ian M. White, Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications, Expert Reviews of Molecular Diagnostics, 13, 49-60, 2013. DOI:10.1586/erm.12.117.

    22. Ian M. White, Soroush H. Yazdi, and Wei W. Yu, Optofluidic SERS: synergizing photonics and microfluidics for chemical and biological analysis, Microfluidics and Nanofluidics, 12, 205-216, 2012. DOI:10.1007/s10404-012-0962-2

    23. Wei W. Yu and Ian M. White, A simple filter-based approach to surface enhanced Raman spectroscopy for trace chemical detection, Analyst, 137, 168-173, 2012. DOI:10.1039/C2AN15947C.

    24. Soroush H. Yazdi and Ian M. White, A nanoporous optofluidic microsystem for highly sensitive and repeatable SERS detection, Biomicrofluidics, 6, 014105, 2012. DOI:10.1063/1.3677369. (selected for publication in the Virtual Journal of Nanoscale Science and Technology and the Virtual Journal of Biological Physics Research)

    25. Xudong Fan and Ian M. White, Optofluidic microsystems for chemical and biological analysis, Nature Photonics, 5, 591-597, 2011. DOI:10.1038/nphoton.2011.206.

    26. I-Jane Chen and Ian M. White, High-sensitivity electrochemical enzyme-linked assay on a microfluidic interdigitated microelectrode, Biosensors and Bioelectronics, 26, 4375-4381, 2011. DOI:10.1016/j.bios.2011.04.044.

    27. Wei W. Yu and Ian M. White, Inkjet Printed Surface Enhanced Raman Spectroscopy Array on Cellulose Paper, Analytical Chemistry 82, 9626-9630, 2010. DOI:10.1021/ac102475k.

    28. Jikun Liu, Ian M. White, and Don L. DeVoe, Nanoparticle-Functionalized Porous Polymer Monolith Detection Elements for Surface-Enhanced Raman Scattering, Analytical Chemistry, 83, 2119-2124, 2011. DOI:10.1021/ac102932d.

    Technical Conferences

    • John P. Goertz and Ian M. White, Covalently Modified Catalytic DNA for Sensitive Analyte Detection via PARCR, Mid-Atlantic DNA Nanotechnology Symposium, 2017, Gaithersburg, MD.

    • Alessandra Zimmermann, Jason Kahn, and Ian M. White, Isothermal DNA Detection Utilizing Bicyclic Amplification of Padlock Probes Mid-Atlantic DNA Nanotechnology Symposium, 2017, Gaithersburg, MD. (poster presentation)

    • John P. Goertz and Ian M. White, Phase-changing partitions for simple automation of multi-step reactions in a single-tube format, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Savannah, Georgia, October 2017.

    • Imaly A. Nanayakkara and Ian M. White, Characterization of Membrane Substrates to Enable DNA Capture and Direct Amplification for Paper-Based Nucleic Acid Amplification Tests, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Savannah, Georgia, October 2017. (poster presentation)

    • Ian M. White (presented by Stephen Restaino), Re-thinking surface enhance Raman spectroscopy (SERS) sensors with a systems perspective, Photonics West, 2017, San Francisco, CA. (Invited presentation)

    • Stephen M. Restaino and Ian M. White, Surface Enhanced Raman Spectroscopy (SERS) methods for endpoint and real-time quantification of miRNA assays, Photonics West, 2017, San Francisco, CA.

    • Adam G. Berger, Stephen M. Restaino, and Ian M. White, Therapeutic drug monitoring in low resource settings with paper SERS, Photonics West, 2017, San Francisco, CA.

    • Adam G. Berger and Ian M. White, Therapeutic Drug Monitoring of Flucytosine in Serum using a SERS-active Membrane System, Photonics West, 2017, San Francisco, CA.

    • Adam G. Berger and Ian M. White, Vertical flow assay and paper SERS for therapeutic drug monitoring of flucytosine from undiluted serum, BMES, 2016, Minneapolis, MN.

    • Imaly A. Nanayakkara and Ian M. White, Simplifying nucleic acid amplification with cell lysis, DNA capture and direct PCR at the surface of chitosan microbeads, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland, October 2016. (poster presentation)

    • Ian M. White, Sample processing and sensing, Optical Biosensors Incubator: Future of Optical Biosensors for Point-of-Care Applications, Washington, D.C., 2015. (Invited presentation)

    • Ian M. White, Inkjet-printed fluidic paper SERS devices for chemical and biological analytics, Advances in Optics for Biotechnology, Medicine, and Surgery XIV, Vail, CO, 2015. (Invited presentation)

    • Ian M. White, SERS-based chemical and biological analytics on inkjet-fabricated paper devices, AVS Mid-Atlantic, Gaithersburg, MD, 2015. (Invited presentation)

    • Stephen M. Restaino and Ian M. White, Inkjet-fabricated surface enhanced Raman spectroscopy (SERS) sensors on paper for biosensing, Photonics West, 2015, San Francisco, CA.

    • John P. Goertz and Ian M. White, Smartphone-enabled filterless fluorescence assay utilizing the pyrene excimer, Photonics West, 2015, San Francisco, CA.

    • Ian M. White, Wei W. Yu, Eric P. Hoppmann, Soroush H. Yazdi, SERS-based biological analytics on inkjet-fabricated paper devices, SciX 2014, Reno, NV (Invited presentation).

    • Ian M. White, Sample preparation for point-of-care bloodstream infection diagnostics, Next Generation Diagnostics Summit 2014, Washington D.C. (Invited presentation).

    • Ian M. White, Surface enhanced Raman spectroscopy sensing of chemical and biological molecules on low-cost microporous devices, Complex Fluids II, 2014, Durham, NC (Invited presentation).

    • Wei W. Yu, Eric P. Hoppmann, and Ian M. White, Inkjet-printed fluidic paper SERS devices for chemical and biological analytics, SciX 2013, Milwaukee, WI (Invited presentation).

    • Ian M. White, Fluidic paper SERS devices for chemical and biological analytics, 2nd European Optical Society Conference on Optofluidics, 2013, Munich, Germany (Invited presentation).

    • Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, SPIE Defense, Security, and Sensing, 2013, Baltimore, MD.

    • Wei W. Yu and Ian M. White, Paper SERS chromatography for detection of trace analytes in complex samples, SPIE Defense, Security, and Sensing, 2013, Baltimore, MD.

    • Eric P. Hoppmann and Ian M. White, A paper-based inkjet-fabricated substrate for SERS detection and differentiation of PCR products, SPIE Defense, Security, and Sensing, 2013, Baltimore, MD.

    • Wei W. Yu and Ian M. White, Inkjet-Fabricated SERS-Active Swab-Dipstick, OSA Optical Sensors, 2012, Monterey, CA.

    • Soroush H. Yazdi and Ian M. White, A Nanoporous Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Melamine, CLEO, 2012, San Jose, CA

    • Wei W. Yu and Ian M. White, Optofluidic SERS on Paper: A Lateral Flow Concentration Assay Using Inkjet Fabricated SERS-Active Substrates, CLEO, 2012, San Jose, CA

    • Ian M. White and Wei W. Yu, Optofluidic SERS on inkjet-fabricated paper-based substrates (Invited presentation), Photonics West, 2012, San Francisco, CA

    • Katayoon Saadin and Ian M. White, Mammosphere culture of cancer stem cells in a microfluidic device, Photonics West, 2012, San Francisco, CA

    • Soroush H. Yazdi and Ian M. White, 3D nanoporous optofluidic device for high sensitivity SERS detection, Photonics West, 2012, San Francisco, CA

    • Ian M. White and Katayoon Saadin, Studying the mechanisms of cancer metastasis in microsystems, Lab on a Chip World Congress, 2011, South San Francisco, CA

    • Ian M. White, Optofluidic biosensors, APC Workshop: Biomedical Optical Sensors - Differentiators for Winning Technologies, 2011, Toronto, ON.

    • Ian M. White, Ink-Jet-Printed Optofluidic SERS for Molecular Analysis (Invited presentation), OSA Optical Sensors, 2011, Toronto, ON.

    • Wei W. Yu and Ian M. White, Paper-based optofluidic SERS using ink-jet-printed substrates, Photonics West 2011, San Francisco, CA.

    • Katayoon Saadin and Ian M. White, A novel microfluidic device for on-chip enrichment of tumorigenic breast cancer cells via mammosphere culture, MRS Fall Meeting 2010, Boston, MA.

    • I-Jane Chen and Ian M. White, Sandwich Structure Electrochemical Assay for Single Stranded DNA Detection, IEEE Sensors 2010, Waikoloa, HI.

    • Kunqiang Jiang, Ian M. White, and Don L. DeVoe, Detection of trace explosives by SERS using 3-D nanochannel arrays, microTAS 2010, Groningen, The Netherlands

    • Jikun Liu, Ian M. White, and Don L. DeVoe, microTAS 2010, Groningen, The Netherlands

    • Jikun Liu, Don L. DeVoe, and Ian M. White, Microfluidic SERS Using a 3-Dimensional Porous Monolith as a SERS-Active Solid Phase in a Microchannel, CLEO 2010, San Jose, CA

    • I-Jane Chen and Ian M. White, Electrochemical Immunoassay for DNA Sensor, Pittcon 2010, Orlando, FL.

    • Eric Hoppmann and Ian M. White, Electrostatic Purification of Nucleic Acids for Micro Total Analysis Systems, Southern Biomedical Engineering Conference 2010, College Park, MD.

    • Farnoosh Farahi and Ian M. White, Integration of Capillary Ring Resonator Biosensor with PDMS Microfluidics for Label-free Biosensing, Southern Biomedical Engineering Conference 2010, College Park, MD.

    • Ian M. White, Optofluidic biosensing for the study of disease at the molecular level (Invited presentation), Photonics West 2010, San Francisco, CA.

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