Molecular and Cellular Bioengineering Research Experiences for Undergraduates (REU) Program
FUNCTIONALIZED HYDROGELS FOR SIGNAL TRANSDUCTION
Bacteria "communicate” with each other through the secretion and perception of small signaling molecules called “autoinducers”. The autoinducers are captured on cell surfaces and internalized, resulting in altered gene regulation (e.g., stimulation of virulence genes). We are creating mimics of the signal molecule, the receptors, and the transduction process that are incorporated into hydrogels. Both synthetic and natural hydrogels are used as scaffolds for the assembly of proteins and receptors that will functionally interrogate the surroundings for the presence of bacteria and, eventually, the eliminate their communication. As a result we expect to reduce virulence of the pathogens—this strategy will lead to next generation antibiotics that target population based behavior and are not based on killing the infecting cells.
Learn About Another Project:
Return to the Projects page »
Return to the REU homepage »
