Molecular and Cellular Bioengineering Research Experiences for Undergraduates (REU) Program

ADAPTIVE RECOGNITION USING VARIOUS TYPES OF CONFORMATIONAL DNA ON GaAs, AlGaAs, AND InAs-BASED SEMICONDUCTORS FOR BIOSENSORS

P.I. Al-Sheikhly
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The objective of this project is to understand the interactions between the DNA and GaAs-based semiconductors to develop biochip modules.  We will use the following thiolated DNAs: aptamers, double helix M-DNA, bending DNA, and other regular single and double stranded DNAs of various lengths.  While the aptamers and bending polymers have been known for their impressive capability to bind (based on their physical structure) with a variety of molecules, short double helix DNAs change their electric conductivity upon interaction with proteins, which allow them to be potential bio-switches and biosensors.  We will also develop biochip sensors based on the attachment of thiolated-DNA on InAs quantum dots, whereby using the strain based self-assembly property of InAs on either GaAs or InP surfaces.  To fulfill the objective of this project, this team will examine the attachment of double helix aptamers on GaAs and light emitting InAs quantum dots. [an error occurred while processing this directive]

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