Fischell Fellow Profiles
Get to know our Fischell Fellows and learn more about their graduate experience. What's their research about, and what could it mean to society? Why did they choose the Clark School and the University of Maryland? What advice do they have for undergraduates considering a graduate degree in Bioengineering?
2014: Kelsey Gray
Kelsey Gray earned a B.S. in chemical engineering and minors in biochemical engineering and biomedical engineering from the University of Delaware in 2012. During her undergraduate career, she accepted a biochemical engineering research internship with Fischell Department of Bioengineering Professor Gregory Payne’s laboratory, where Gray worked on an industry-university team developing immunosensors for point-of-care diagnostics, and gained experience translating academic research into medical technology.
As a member of Assistant Professor Kimberly Stroka’s Cell and Microenvironment Engineering Lab, Gray’s goal is to develop a blood-brain barrier-on-a-chip that will ultimately have a significant clinical impact. . Design of this model will provide a wide variety of opportunity for scientific advancement—from understanding fundamental biological phenomenon to drug development and screening. This model could be used in the context of various diseases involving blood-brain barrier dysfunction—cancer, Alzheimer’s, Parkinson’s, multiple sclerosis, and more—as well as in a healthy context, studying the ability of new drugs to cross the barrier.
Outside the lab, Gray is a mentor for both Wheaton High School and Elizabeth Seton High School students, and a member of the International Society for Pharmaceutical Engineers, Phi Sigma Pi National Honor Fraternity, and the National Society of Collegiate Scholars. In her free time, she enjoys DIY projects, trying new foods, and boating on the Chesapeake Bay.
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2013: John Goertz
After attending high school in Anchorage, Alaska, John Goertz earned his B.S. in physics and cell biology from Seattle University. He decided to combine and use his undergraduate experiences in physics and biology to pursue a career in bioengineering, a field in which he hopes to have an international impact on human health. At the Clark School, he would like to develop low-cost, portable tools for infectious disease diagnostics for use in resource-poor areas. "What attracted me to [the Fischell Department of] Bioengineering at the University of Maryland was the not just its focus on bringing new biomedical tools to the market, but also that the department is very engaged in creating technologies accessible to all socioeconomic tiers," he says.
John's prior research includes atomic force microscopy (AFM) analysis of the interactions between the chaperone protein hsp90 and its client protein, the glucocorticoid receptor, and the creation of MATLAB-based program to aid in the analysis of the AFM images. He has also studied quasi-two-dimensional fluid dynamics, examining the interplay of surface friction, viscosity, and flow speed profiles on vortex shedding, and finding potential flaws in common assumptions made when adapting the well-known Roschko formula from three to two dimensions.
Outside of the lab, John enjoys hiking, cooking, brewing, and practicing the martial art Danzan-Ryu Jujitsu.
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2012: Mina Choi
Advisor: Aldo Badano, FDA, Center for Devices and Radiological Health
Mina Choi's previous research experience includes a project that visualized the effects of violent computer games on the brain using EEG at Iowa State University; the design of a neonatal seizure detection algorithm in collaboration with neurologist Dr. Taeun Chang at the Children’s National Medical Center; modeling traumatic brain injury using high intensity focused ultrasound under the guidance of Dr. Vesna Zderic (GWU) and Dr. Matthew Myers (U.S. Food and Drug Administration [FDA]); and her masters thesis under Dr. Aldo Badano (FDA), measuring veiling glare in high-dynamic-range displays and in the human eye. After completing her M.S., she continued her work with Badano as an ORISE Fellow for two years before returning to graduate school. At the Clark School, Mina is interested in pursuing research in medical imaging and simulations. Outside of the lab, she enjoys playing guitar, gaming, hiking and travel. Her past trips include missions to assist dentists in Gambia and to farm and teach in Kyrgyzstan.
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2011: Anthony Melchiorri
Advisor: John Fisher
Anthony Melchiorri earned a B.S.E in biomedical engineering and a B.A in English from the University of Iowa in 2011. Throughout his time as an undergraduate, he was actively engaged in cardiovascular research in academic and industrial internships, including studies involving cardiomyogenic differentiation of mesenchymal stem cells and heart-related biomedical devices. At the Clark School, he hopes to pursue research in cardiovascular therapies that will ultimately have a significant clinical impact. After earning his Ph.D. would like to launch his own biotech company. "I chose the Fischell Department of Bioengineering because of the variety of opportunities available to BioE graduate students," he says. "The [department's] collaborations with and proximity to the FDA and NIH...provided additional benefits for a student like me, [who is] interested in pursuing research as a career and especially interested in commercialization of medical therapies…The entrepreneurship program [at the Maryland Technology Enterprise Institute] was another influencing factor."
Tony conducts his research in the Tissue Engineering and Biomaterials Lab, where he is developing biodegradable, polymeric vascular grafts. His work is focused on modifying the grafts' surfaces in ways that will increase endothelial cell and endothelial progenitor cell attachment and proliferation. To accomplish this, he is examining both chemical and topological enhancements. He is also exploring the use of 3D printing technology to create tissue engineering scaffolds and other potential medical devices out of the biodegradable polymers synthesized in the lab.
Outside of the lab, Tony enjoys fiction writing, reading, volunteer activities, scuba diving, and playing blues guitar.
In addition to being a Fischell Fellow, he is also a Citrin Fellow and a NSF Fellow.
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2010: Sean Virgile
Advisor: Ian White
Sean Virgile received his B.S. in biomedical engineering from the University of Rochester in May 2010. While an undergraduate, he was named the Barry M. Goldwater Scholar in the spring of 2009. His interests include microfluidics, early cancer detection, and bringing new technologies from the lab to the market. "I chose Maryland," he says, "because of the close-knit community between students and professors, the ease of turning research ideas into start-up companies at Mtech, and the large number of opportunities to perform research not only on campus but also at government facilities such as the FDA and NIH." Sean conducts his research in the Photonic Biosensors Laboratory, where he is designing novel, cost-effective viral DNA/RNA molecular probes for a rapid point-of-care biosensor. He is also one of the co-founders Diagnostic anSERS. The startup company produces a system that uses an inkjet printer and nanoparticle-laced ink to print sensors that can be created on-demand, on location, and at a much lower cost than its nearest competitors.
Read related news stories about Sean:
- Diagnostic anSERS Takes 3rd and UMD Prize at Cupid's Cup Finals
- Two BioE/ISR Professors Receive Maryland Industrial Partnership Funding
- Diagnostic anSERS Heads to Cupid's Cup Finals
- Diagnostic anSERS Pitches Dingman...and Wins!
- BioE Teams at $75K Business Plan Competition Finals
- Virgile Named 2010 Fischell Fellow
2009: Deborah Sweet Goldberg
Advisors: Hamid Ghandehari (University of Utah) and Peter Swaan (University of Maryland School of Pharmacy)
Deborah earned her B.S. in chemical engineering from the University of Maryland in 2006. She conducts her graduate research at advisor Peter Swaan's Center for Nanomedicine & Cellular Delivery, where she is developing an oral delivery system for chemotherapy drugs that are traditionally administered intravenously. Any drug involved in an oral chemotherapy solution would need to survive the harsh environments in the stomach and intestines, pass through the intestinal wall, find its target, and treat a tumor as effectively as an intravenously-delivered drug could. It's a difficult problem but the payoff is a better quality of life for cancer patients, who could receive their treatments at home, and possibly with fewer side effects. Deborah's strategy is to use dendrimers—nano-sized, highly branched synthesized polymers with defined, controllable structures—as carriers for 5-FU, a common chemotherapy drug. Deborah says the process of becoming a Fischell Fellow has taught her a lot about the FDA approval process and what goes into commercializing a new drug. Her experiences at Maryland, she says, are preparing her for her ultimate goal of conducting pharmaceutical or biotechnology research and development in industry.
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2008: Marc Dandin
Advisors: Pamela Abshire (Electrical and Computer Engineering) and Elisabeth Smela (Mechanical Engineering)
Marc earned a B.S. and M.S. in electrical engineering at the University of Maryland before becoming a doctoral student in the Fischell Department of Bioengineering. Currently, he divides his time between the Integrated Biomorphic Information Systems Laboratory and the Laboratory for Microtechnologies, where, using "lab on a chip" technology, he is developing a hand-held, optoelectronic microsystem-based biosensor capable of detecting dangerous pathogens present in quantities of only 10-50 cells, then reporting results within minutes. Microfluidic channels will route and analyze nanoliter samples taken from suspect food or water, scanning them for autofluorescence indicative of live pathogen activity. Since autofluorescence is common to many kinds of cells, the device's microfluidic channels must be lined with molecules capable of filtering a sample for the target pathogen(s), and also requires the design of an imaging system sensitive enough to detect light emitted from so few cells. Marc says the interdisciplinary nature of the Fischell Department of Bioengineering and access to advanced, flexible facilities like the NanoCenter's FabLab are what make research like his possible.
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2007: Dan Janiak
Advisor: Peter Kofinas
Dan, who earned his B.S. in materials science and engineering at University of Maryland, engineered molecularly imprinted polymer hydrogels capable of recognizing and capturing specific peptides, proteins, and larger macromolecular structures—in his case, viruses. In diagnostic and treatment applications, the hydrogels could be used in blood tests as a means of detecting viral infection, for biological threat detection, and in hemodialysis to filter toxins from the blood. The award-winning technology could be integrated into existing medical equipment at a low cost to hospitals and other healthcare facilities, and has already been licensed for further development. Dan's work could also benefit vaccine production by speeding up the filtering of the biomasses from which inactive virus particles are obtained. In addition to his virus-filtering research, Dan has helped create polymer-based products that could be used in packaging to alert consumers to contaminated food, and for blood clotting. He credits the Fischell Fellowship for sparking his interest in entrepreneurship and prompting him to think outside the lab. "It [made me] appreciate what people do to take technology from the lab to industry," he says.
Read related news stories about Dan's research:
- Janiak Named Kauffman Fellow
- "Virus Sponge" Could Improve Flu Treatments
- Company to Utilize Kofinas's, Janiak's MIPs Technology
- Kofinas, Janiak Take 1st Place in Business Plan Competition
- Kofinas Group Wins 2nd Business Plan Competition
2006: Diana Yoon
Advisor: John Fisher
Diana, who earned a B.S. in Chemical Engineering from Carnegie Mellon University, joined Dr. John Fisher's Tissue Engineering and Biomaterials Laboratory the year it was launched. "I felt he was, like me, very goal-oriented," she recalls. He was very clear about what he thought I could accomplish." She ultimately choose UMD because she felt it fostered not only great research, but also solid academic, professional, and social relationships. During her time at the University of Maryland, Diana explored the design of novel, injectable, biodegradable polymer hydrogels as a support structure for the regrowth of knee cartilage, and conducted in vitro studies to determine the best growing conditions for cartilage tissue within them. The injection of a hydrogel containing healthy cartilage cells into a patient's damaged knee is far less invasive than traditional knee surgery, resulting in less damage to the body, less inflammation, fewer immune responses, and a shorter recovery time. If the implementation is ultimately successful, the implanted cells would grow as the hydrogel safely degrades, leaving behind new, functional cartilage.
2005: Matt Dowling
Advisor: Srinivasa Raghavan (Department of Chemical and Biomolecular Engineering)
Matt's research in the Complex Fluids & Nanomaterials Group focused on soft matter, materials that are deformable solids or highly viscoelastic liquids. Dowling drew inspiration from biology by designing biomaterials that self assemble and are similar in structure to cells and their organelles to design four soft matter systems: a triggered-release hydrogel created by embedding pH-sensitive vesicles in a gelatin matrix; hybrid biopolymer capsules containing drug-loaded vesicles (hollow spheres made out of lipids) by means of a one-step self-assembly process; therapeutically functionalized biopolymer films; and a biopolymer that transforms a suspension of whole blood or soft tissue cells into a gel. The last application became the driving force behind Remedium Technologies, an award-winning startup company he founded with other graduate students and postdocs in his lab. Remedium's blood-clotting wound care products include a surgical spray, a foam for non-compressible injuries, a "biobandage", and a surgical spray.
Read related news stories about Matt's research:
Remedium Technologies Inc. Awarded $500,000 Phase II NSF SBIR Grant to Test Sprayable Foam for Stopping Traumatic Bleeding (PDF; Remedium Technologies press release)
- Blood-Clotting "Nano-Velcro" Featured in C&EN
- Mtech, Alumna-Run Companies Vie for State Awards
- Dowling Wins Dean's Doctoral Research Award Competition
- Remedium Wins ORNL Global Venture Challenge
- Remedium Wins $10K in Global Security Challenge
- Dowling Named A Maryland Innovator of the Year
- "Nano-Velcro" Wins Outstanding Invention of the Year
2003: Angela Hodge-Miller
Angela, our first Fischell Fellow, received her bachelor's degree in electrical engineering from the University of Maryland in 1996 and her master's degree in electrical engineering from Stanford in 1998. Her Ph.D. research focused on the design of chemical sensors that could accelerate the detection of toxins like anthrax. She developed systems-on-a-chip capable of performing selective determination of compounds in a variety of fluids, such as blood, urine and saliva. By reproducing multiple laboratory capabilities on a portable, handheld device, she hoped to enable real-time, on-site analysis that could save lives through faster diagnosis.