Clark School Home
BioE Home
Return to Faculty Directory »  |  Return to Laboratories »

White, Ian

Ian White


Research Interests 

Disease detection, optical biosensors, ring resonators, SERS, lab-on-a-chip.

Education 

Ph.D., Stanford University, 2002

Current Research Projects 

The White Research Group develops integrated microsystems for the diagnosis and study of disease at the cellular and molecular level. Using a combination of microfabrication techniques, we are implementing micro total analysis systems (uTAS) for three major research thrusts.

  1. Infectious disease detection. Using novel techniques, we aim to implement a uTAS that concentrates pathogens from large volume samples, recovers nucleic acids, and quantifies pathogens in the sample based on DNA signature biosensing.
  2. Understanding cancer metastasis. We are developing a new on-chip assay to identify and enrich highly tumorigenic cells using techniques in microfabrication, chemistry, and cancer biology.
  3. Point-of-sample chemical/biomolecule detection. We have developed novel 3D optofluidic surface enhanced Raman spectroscopy (SERS) scaffolds in uTAS devices to enable low-cost portable detection of chemicals and biomolecules, including pesticides, explosives, and industrial toxins.

Selected Publications 

Wei W. Yu and Ian M. White, Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates, Analyst, in press.

Katayoon Saadin, Jeffrey M. Burke, Neerav P. Patel, Rebecca E. Zubajlo, and Ian M. White, Enrichment of tumor-initiating breast cancer cells within a mammosphere-culture microdevice, Biomedical Microdevices, DOI:10.1007/s10544-013-9755-y.

Wei W. Yu and Ian M. White, Inkjet-Printed Paper-Based SERS Dipsticks and Swabs for Trace Chemical Detection, Analyst, 138, 1020-1025, 2013. DOI:10.1039/C2AN36116G. (outside front cover)

Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, 138, 100-103, 2013. DOI:10.1039/C2AN36232E.

Soroush H. Yazdi and Ian M. White, An Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Chemical Contaminants, Analytical Chemistry, 84, 7992-7998, 2012. DOI:10.1021/ac301747b.

Katayoon Saadin and Ian M. White, Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications, Expert Reviews of Molecular Diagnostics, 13, 49-60, 2013. DOI:10.1586/erm.12.117.

Ian M. White, Soroush H. Yazdi, and Wei W. Yu, Optofluidic SERS: synergizing photonics and microfluidics for chemical and biological analysis, Microfluidics and Nanofluidics, 12, 205-216, 2012. DOI:10.1007/s10404-012-0962-2

Wei W. Yu and Ian M. White, A simple filter-based approach to surface enhanced Raman spectroscopy for trace chemical detection, Analyst, 137, 168-173, 2012. DOI:10.1039/C2AN15947C.

Soroush H. Yazdi and Ian M. White, A nanoporous optofluidic microsystem for highly sensitive and repeatable SERS detection, Biomicrofluidics, 6, 014105, 2012. DOI:10.1063/1.3677369. (selected for publication in the Virtual Journal of Nanoscale Science and Technology and the Virtual Journal of Biological Physics Research)

Xudong Fan and Ian M. White, Optofluidic microsystems for chemical and biological analysis, Nature Photonics, 5, 591-597, 2011. DOI:10.1038/nphoton.2011.206.

I-Jane Chen and Ian M. White, High-sensitivity electrochemical enzyme-linked assay on a microfluidic interdigitated microelectrode, Biosensors and Bioelectronics, 26, 4375-4381, 2011. DOI:10.1016/j.bios.2011.04.044.

Wei W. Yu and Ian M. White, Inkjet Printed Surface Enhanced Raman Spectroscopy Array on Cellulose Paper, Analytical Chemistry 82, 9626-9630, 2010. DOI:10.1021/ac102475k.

Jikun Liu, Ian M. White, and Don L. DeVoe, Nanoparticle-Functionalized Porous Polymer Monolith Detection Elements for Surface-Enhanced Raman Scattering, Analytical Chemistry, 83, 2119-2124, 2011. DOI:10.1021/ac102932d.

I. M. White and X. Fan, "On the performance quantification of resonant refractive index sensors," Optics Express 16, 1020-1028 (2008).

I. M. White, J. Gohring, and X. Fan, "SERS-based detection in an optofluidic ring resonator platform," Optics Express 15, 17433-17442 (2007).

I. M. White, J. Gohring, Y. Sun, G. Yang, S. Lacey, and X. Fan, "Versatile waveguide-coupled opto-fluidic devices based on liquid core optical ring resonators," Applied Physics Letters 94, 241104 (2007).

I. M. White, J. D. Suter, H. Oveys, X. Fan, T. L. Smith, J. Zhang, B. J. Koch, and M. A. Haase, "Universal coupling between metal-clad waveguides and optical ring resonators," Optics Express 15, 646-651 (2007).

I. M. White, H. Zhu, J. D. Suter, N. M. Hanumegowda, H. Oveys, M. Zourob, and X. Fan, "Refractometric Sensors for Lab-on-a-Chip Based on Optical Ring Resonators," IEEE Sensors Journal 7, 28-35 (2007).

I. M. White, H. Oveys, X. Fan, T. L. Smith, and J. Zhang, "Integrated Multiplexed Biosensors Based on Liquid Core Optical Ring Resonators and Anti-Resonant Reflecting Optical Waveguide," Applied Physics Letters 89, 191106 (2006).

I. M. White, H. Oveys, and X. Fan, "Increasing the enhancement of SERS with dielectric microsphere resonators," April 1 issue of Spectroscopy (2006).

I. M. White, H. Oveys, and X. Fan, "Liquid Core Optical Ring Resonator Sensors," Optics Letters 31, 1319-1321 (2006).

Selected Presentations 

Wei W. Yu and Ian M. White, Inkjet-Fabricated SERS-Active Swab-Dipstick, OSA Optical Sensors, 2012, Monterey, CA.

Soroush H. Yazdi and Ian M. White, A Nanoporous Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Melamine, CLEO, 2012, San Jose, CA

Wei W. Yu and Ian M. White, Optofluidic SERS on Paper: A Lateral Flow Concentration Assay Using Inkjet Fabricated SERS-Active Substrates, CLEO, 2012, San Jose, CA

Ian M. White and Wei W. Yu, Optofluidic SERS on inkjet-fabricated paper-based substrates (Invited presentation), Photonics West, 2012, San Francisco, CA

Katayoon Saadin and Ian M. White, Mammosphere culture of cancer stem cells in a microfluidic device, Photonics West, 2012, San Francisco, CA

Soroush H. Yazdi and Ian M. White, 3D nanoporous optofluidic device for high sensitivity SERS detection, Photonics West, 2012, San Francisco, CA

Ian M. White and Katayoon Saadin, Studying the mechanisms of cancer metastasis in microsystems, Lab on a Chip World Congress, 2011, South San Francisco, CA

Ian M. White, Optofluidic biosensors, APC Workshop: Biomedical Optical Sensors - Differentiators for Winning Technologies, 2011, Toronto, ON.

Ian M. White, Ink-Jet-Printed Optofluidic SERS for Molecular Analysis (Invited presentation), OSA Optical Sensors, 2011, Toronto, ON.

Wei W. Yu and Ian M. White, Paper-based optofluidic SERS using ink-jet-printed substrates, Photonics West 2011, San Francisco, CA.

Katayoon Saadin and Ian M. White, A novel microfluidic device for on-chip enrichment of tumorigenic breast cancer cells via mammosphere culture, MRS Fall Meeting 2010, Boston, MA.

I-Jane Chen and Ian M. White, Sandwich Structure Electrochemical Assay for Single Stranded DNA Detection, IEEE Sensors 2010, Waikoloa, HI.

Kunqiang Jiang, Ian M. White, and Don L. DeVoe, Detection of trace explosives by SERS using 3-D nanochannel arrays, microTAS 2010, Groningen, The Netherlands

Jikun Liu, Ian M. White, and Don L. DeVoe, microTAS 2010, Groningen, The Netherlands

Jikun Liu, Don L. DeVoe, and Ian M. White, Microfluidic SERS Using a 3-Dimensional Porous Monolith as a SERS-Active Solid Phase in a Microchannel, CLEO 2010, San Jose, CA

I-Jane Chen and Ian M. White, Electrochemical Immunoassay for DNA Sensor, Pittcon 2010, Orlando, FL.

Eric Hoppmann and Ian M. White, Electrostatic Purification of Nucleic Acids for Micro Total Analysis Systems, Southern Biomedical Engineering Conference 2010, College Park, MD.

Farnoosh Farahi and Ian M. White, Integration of Capillary Ring Resonator Biosensor with PDMS Microfluidics for Label-free Biosensing, Southern Biomedical Engineering Conference 2010, College Park, MD.

Ian M. White, Optofluidic biosensing for the study of disease at the molecular level (Invited presentation), Photonics West 2010, San Francisco, CA.

Related News 

Hydrophobically Modified Polymers Create “Cell Gels”
New technique could be used in tissue engineering, 3D cell culture. August 11, 2014

September 1, 2014 Submission Deadline
An announcement of Request for Proposals for M-CERSI Science Exchange and Conference Grants. July 25, 2014

Diagnostic anSERS introduces SERS sensor 'for the mainstream'
UMD alumni/student company's product can detect trace chemicals for only a few dollars per test. June 13, 2014

Clark School Faculty Promotions Announced
Faculty promoted to full professor, associate professor with tenure. June 5, 2014

BioE Capstone 2014: New Projects Focus on Cardiological Health, Surgical Tools and More
Students' inventions range from diagnostic devices to accident prevention products. June 4, 2014

Regulatory Science Competition Winners Present Concepts to FDA
UMD and UR competition winners present competition concepts to the FDA. May 5, 2014

White Receives E. Robert Kent Outstanding Teaching Award for Junior Faculty
Professor honored at 2013 winter commencement. January 6, 2014

UMD Launches Online Course for Transitioning Service Members and Veterans on Energy Problem Solving
Engineering course supported by Department of Defense will focus on design skills December 10, 2013

ResearchFest 2013
ResearchFest 2013 September 22, 2013

Shapiro, Yu Win 2013 BioE Teaching, Graduate Research Awards
Honors presented at annual "Welcome Back" seminar. September 9, 2013

BioE Capstone 2013: New Products Focus on Diagnostics, Physical Therapy and More
Students' inventions address needs ranging from home care to ICU. July 11, 2013

Hoppmann Wins GRID Division for Presentation on Dipstick Sensors
Technology could be used for fast, efficient diagnosis of infectious disease. May 1, 2013

2012-2013 BioE Undergraduate Awards
Exceptional students recognized at annual ceremony. April 9, 2013

Diagnostic anSERS Takes 3rd and UMD Prize at Cupid's Cup Finals
Startup wins $10,000, plans to scale up manufacturing. April 8, 2013

UMD and JHU Students Join Forces for Research Day
"Amplifying the Field" celebrates undergraduate contributions to biomedical research. March 13, 2013

Two BioE/ISR Professors Receive Maryland Industrial Partnership Funding
Diagnostic anSERS and Cordex Systems primed for further development of sensors, device for detection of heart disease. February 26, 2013

Diagnostic anSERS Heads to Cupid's Cup Finals
Printed sensors team to vie for $70,000 in April. February 26, 2013

Chen Bioimaging Research Wins Prestigious NSF CAREER Award
Grant supports improvements to neural imaging and image-guided neurosurgery. November 20, 2012

Diagnostic anSERS Pitches Dingman...and Wins!
BioE startup company wins funding for paper-based sensor product. November 5, 2012

White Group Sensors Paper a Royal Society of Chemistry Hot Pick
P-SERS technology to be featured on cover of Analyst. September 20, 2012

Capstone 2012: Innovations in Emergency Medicine, Diagnostic Tools, Physical Therapy, and More
BioE seniors present an array of new devices for improving health and safety. May 18, 2012

Abutaleb and Ruppel Named Stamps Banneker/Key Scholars
Two incoming Clark School freshmen honored with full scholarships. May 17, 2012

BioE Teams at $75K Business Plan Competition Finals
New companies pitch products for food safety, diagnostics, detection of toxins. April 25, 2012

Yu Takes Second at GRID Session for Advances in Sensor Technology
Grad student presents new alternatives to traditional SERS substrates. April 24, 2012

Gulick Named One of Glamour Magazine's Top 10 College Women
BioE junior is a top cyclist. April 6, 2012

New Awards Support Research on Neonatal Ventilator Safety, Viral Diagnostics
Shapiro, White receive inaugural innovation grants from UM-CERSI. April 5, 2012

White Receives Best Paper Award from Sensors
Top journal recognizes work on new biosensor technology. February 24, 2012

White's Research Wins Prestigious NSF CAREER Award
Inkjet-printed paper biosensors will reduce cost of diagnosing epidemic pathogens. February 3, 2012

Novel Biophysical Models Help Explain Mechanics of Cardiovascular Disease
Stroka, Aranda-Espinoza publish results in Blood. September 19, 2011

$1.35M For New Study of Cell Migration
Aranda-Espinoza wins Human Frontier Science Program research grant. August 25, 2011

Inoue Joins BioE as Professor of the Practice
Canon U.S. Life Sciences senior fellow developing system for rapid diagnosis of disease. August 4, 2011

Xie in Washington Post, Interviewed for "Top Line"…and Meets with President Obama!
BioE major and undergraduate student body president represents student constituents in debt ceiling debate. August 3, 2011

Canon U.S. Life Sciences and the University of Maryland Launch New Collaboration
Joint team to develop automated machine designed to expedite the diagnosis of infectious diseases. July 19, 2011

Capstone 2011: Improved Diagnostics and Monitoring, Surgical Devices, and Personal Technology
Learn about new products from tomorrow's innovators. June 2, 2011

Yu's Printed Paper Sensors Talk Wins GRID Session
Grad student recognized for novel approach to spectroscopy. April 25, 2011

Ink Jet Printer Could Make Advanced Analysis Affordable, Accessible
White, Yu publish experiments with off-the-shelf products that could make spectroscopy easier for labs; new technique covered by CE&N. November 23, 2010

BioE Hosts Teachers in NSF-Sponsored Program
Summer workshop will improve K-12 engineering, math education. July 26, 2010

Capstone 2010: Devices for Diagnostics, Improved Treatments, and Personal Health
See projects from tomorrow's innovators. May 18, 2010

Stroka Wins NIH Grant for Cardiovascular Research
Ruth L. Kirschstein National Research Service Award will fund work on the biophysics of cell transmigration through the vascular endothelium. January 19, 2010

Dowling Named A Maryland Innovator of the Year
Fischell Fellow garners new award for blood-clotting technology. October 19, 2009

Capstone 2009: Devices for Doctors, Caregivers, Patients and Public Health
See projects from tomorrow's innovators. May 18, 2009

Herold Edits 2 Vol. Book on Biosensors, Biodetection
Titles part of Methods in Molecular Biology series. January 9, 2009

Honor for Hybrid Power System Inventor
Alex Severinsky is 2008 Clark School Innovation Hall of Fame inductee.
September 11, 2008

UM a Leader in Black Ph.D.'s
NSF report: UM near top in black undergrads who pursue Ph.D.'s in science, engineering. September 10, 2008

BioE Welcomes 3 New Faculty Members
Balaras, Muro and White arrive for Fall '08. August 27, 2008

Experts Explore Environmental Engineering
White Symposium speakers outline characteristics of great engineers and programs. October 5, 2007

Renowned Telecom Experts to Deliver White Symposium
October 16 event will feature Barry West, Andrew Viterbi and Rajiv Laroia. September 20, 2006

FDA Acting Commissioner Visits Bioengineering
von Eschenbach cites the importance of the FDA's link with the University. September 14, 2006