Disease detection, optical biosensors, ring resonators, SERS, lab-on-a-chip.
Ph.D., Stanford University, 2002
Current Research Projects
The White Research Group develops integrated microsystems for the diagnosis and study of disease at the cellular and molecular level. Using a combination of microfabrication techniques, we are implementing micro total analysis systems (uTAS) for three major research thrusts.
- Infectious disease detection. Using novel techniques, we aim to implement a uTAS that concentrates pathogens from large volume samples, recovers nucleic acids, and quantifies pathogens in the sample based on DNA signature biosensing.
- Understanding cancer metastasis. We are developing a new on-chip assay to identify and enrich highly tumorigenic cells using techniques in microfabrication, chemistry, and cancer biology.
- Point-of-sample chemical/biomolecule detection. We have developed novel 3D optofluidic surface enhanced Raman spectroscopy (SERS) scaffolds in uTAS devices to enable low-cost portable detection of chemicals and biomolecules, including pesticides, explosives, and industrial toxins.
Wei W. Yu and Ian M. White, Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates, Analyst, in press.
Katayoon Saadin, Jeffrey M. Burke, Neerav P. Patel, Rebecca E. Zubajlo, and Ian M. White, Enrichment of tumor-initiating breast cancer cells within a mammosphere-culture microdevice, Biomedical Microdevices, DOI:10.1007/s10544-013-9755-y.
Wei W. Yu and Ian M. White, Inkjet-Printed Paper-Based SERS Dipsticks and Swabs for Trace Chemical Detection, Analyst, 138, 1020-1025, 2013. DOI:10.1039/C2AN36116G. (outside front cover)
Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, 138, 100-103, 2013. DOI:10.1039/C2AN36232E.
Soroush H. Yazdi and Ian M. White, An Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Chemical Contaminants, Analytical Chemistry, 84, 7992-7998, 2012. DOI:10.1021/ac301747b.
Katayoon Saadin and Ian M. White, Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications, Expert Reviews of Molecular Diagnostics, 13, 49-60, 2013. DOI:10.1586/erm.12.117.
Ian M. White, Soroush H. Yazdi, and Wei W. Yu, Optofluidic SERS: synergizing photonics and microfluidics for chemical and biological analysis, Microfluidics and Nanofluidics, 12, 205-216, 2012. DOI:10.1007/s10404-012-0962-2
Wei W. Yu and Ian M. White, A simple filter-based approach to surface enhanced Raman spectroscopy for trace chemical detection, Analyst, 137, 168-173, 2012. DOI:10.1039/C2AN15947C.
Soroush H. Yazdi and Ian M. White, A nanoporous optofluidic microsystem for highly sensitive and repeatable SERS detection, Biomicrofluidics, 6, 014105, 2012. DOI:10.1063/1.3677369. (selected for publication in the Virtual Journal of Nanoscale Science and Technology and the Virtual Journal of Biological Physics Research)
Xudong Fan and Ian M. White, Optofluidic microsystems for chemical and biological analysis, Nature Photonics, 5, 591-597, 2011. DOI:10.1038/nphoton.2011.206.
I-Jane Chen and Ian M. White, High-sensitivity electrochemical enzyme-linked assay on a microfluidic interdigitated microelectrode, Biosensors and Bioelectronics, 26, 4375-4381, 2011. DOI:10.1016/j.bios.2011.04.044.
Wei W. Yu and Ian M. White, Inkjet Printed Surface Enhanced Raman Spectroscopy Array on Cellulose Paper, Analytical Chemistry 82, 9626-9630, 2010. DOI:10.1021/ac102475k.
Jikun Liu, Ian M. White, and Don L. DeVoe, Nanoparticle-Functionalized Porous Polymer Monolith Detection Elements for Surface-Enhanced Raman Scattering, Analytical Chemistry, 83, 2119-2124, 2011. DOI:10.1021/ac102932d.
I. M. White and X. Fan, "On the performance quantification of resonant refractive index sensors," Optics Express 16, 1020-1028 (2008).
I. M. White, J. Gohring, and X. Fan, "SERS-based detection in an optofluidic ring resonator platform," Optics Express 15, 17433-17442 (2007).
I. M. White, J. Gohring, Y. Sun, G. Yang, S. Lacey, and X. Fan, "Versatile waveguide-coupled opto-fluidic devices based on liquid core optical ring resonators," Applied Physics Letters 94, 241104 (2007).
I. M. White, J. D. Suter, H. Oveys, X. Fan, T. L. Smith, J. Zhang, B. J. Koch, and M. A. Haase, "Universal coupling between metal-clad waveguides and optical ring resonators," Optics Express 15, 646-651 (2007).
I. M. White, H. Zhu, J. D. Suter, N. M. Hanumegowda, H. Oveys, M. Zourob, and X. Fan, "Refractometric Sensors for Lab-on-a-Chip Based on Optical Ring Resonators," IEEE Sensors Journal 7, 28-35 (2007).
I. M. White, H. Oveys, X. Fan, T. L. Smith, and J. Zhang, "Integrated Multiplexed Biosensors Based on Liquid Core Optical Ring Resonators and Anti-Resonant Reflecting Optical Waveguide," Applied Physics Letters 89, 191106 (2006).
I. M. White, H. Oveys, and X. Fan, "Increasing the enhancement of SERS with dielectric microsphere resonators," April 1 issue of Spectroscopy (2006).
I. M. White, H. Oveys, and X. Fan, "Liquid Core Optical Ring Resonator Sensors," Optics Letters 31, 1319-1321 (2006).
Wei W. Yu and Ian M. White, Inkjet-Fabricated SERS-Active Swab-Dipstick, OSA Optical Sensors, 2012, Monterey, CA.
Soroush H. Yazdi and Ian M. White, A Nanoporous Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Melamine, CLEO, 2012, San Jose, CA
Wei W. Yu and Ian M. White, Optofluidic SERS on Paper: A Lateral Flow Concentration Assay Using Inkjet Fabricated SERS-Active Substrates, CLEO, 2012, San Jose, CA
Ian M. White and Wei W. Yu, Optofluidic SERS on inkjet-fabricated paper-based substrates (Invited presentation), Photonics West, 2012, San Francisco, CA
Katayoon Saadin and Ian M. White, Mammosphere culture of cancer stem cells in a microfluidic device, Photonics West, 2012, San Francisco, CA
Soroush H. Yazdi and Ian M. White, 3D nanoporous optofluidic device for high sensitivity SERS detection, Photonics West, 2012, San Francisco, CA
Ian M. White and Katayoon Saadin, Studying the mechanisms of cancer metastasis in microsystems, Lab on a Chip World Congress, 2011, South San Francisco, CA
Ian M. White, Optofluidic biosensors, APC Workshop: Biomedical Optical Sensors - Differentiators for Winning Technologies, 2011, Toronto, ON.
Ian M. White, Ink-Jet-Printed Optofluidic SERS for Molecular Analysis (Invited presentation), OSA Optical Sensors, 2011, Toronto, ON.
Wei W. Yu and Ian M. White, Paper-based optofluidic SERS using ink-jet-printed substrates, Photonics West 2011, San Francisco, CA.
Katayoon Saadin and Ian M. White, A novel microfluidic device for on-chip enrichment of tumorigenic breast cancer cells via mammosphere culture, MRS Fall Meeting 2010, Boston, MA.
I-Jane Chen and Ian M. White, Sandwich Structure Electrochemical Assay for Single Stranded DNA Detection, IEEE Sensors 2010, Waikoloa, HI.
Kunqiang Jiang, Ian M. White, and Don L. DeVoe, Detection of trace explosives by SERS using 3-D nanochannel arrays, microTAS 2010, Groningen, The Netherlands
Jikun Liu, Ian M. White, and Don L. DeVoe, microTAS 2010, Groningen, The Netherlands
Jikun Liu, Don L. DeVoe, and Ian M. White, Microfluidic SERS Using a 3-Dimensional Porous Monolith as a SERS-Active Solid Phase in a Microchannel, CLEO 2010, San Jose, CA
I-Jane Chen and Ian M. White, Electrochemical Immunoassay for DNA Sensor, Pittcon 2010, Orlando, FL.
Eric Hoppmann and Ian M. White, Electrostatic Purification of Nucleic Acids for Micro Total Analysis Systems, Southern Biomedical Engineering Conference 2010, College Park, MD.
Farnoosh Farahi and Ian M. White, Integration of Capillary Ring Resonator Biosensor with PDMS Microfluidics for Label-free Biosensing, Southern Biomedical Engineering Conference 2010, College Park, MD.
Ian M. White, Optofluidic biosensing for the study of disease at the molecular level (Invited presentation), Photonics West 2010, San Francisco, CA.