Vaccine design and immunotherapy, biomaterial interactions with the immune system, autoimmunity, polyelectrolyte multilayers, nanotechnology, polymer and lipid-based drug carriers.
Postdoctoral Fellow, MIT 2009-2012
Ph.D., University of Wisconsin–Madison, 2008
Honors and Awards
- Featured in USA Today "New Faces of Engineering" during National Engineers Week (2012)
- American Association of Immunologists Trainee Award (2012)
- Burroughs Wellcome Fund Career Award at Scientific Interface– Semifinalist (2012)
- Controlled Release Society T. Nagai Postdoctoral Research Achievement Award (2011)
- Ragon Institute of MGH, MIT, and Harvard Science Symposium–Best Poster recipient (2011)
- Society for Biomaterials STAR award (2011)
- American Chemical Society Postdoc-to-Faculty Program–Invitee and participant (2010)
- Ragon Institute of MGH, MIT, and Havard Postdoctoral Fellowship (2009-2011)
- The Boston Consulting Group Social Impact Fellow–New Zealand conservation work (2008)
- National Institutes of Health Graduate Student Research Festival–Invitee and presenter (2007)
- National Science Foundation Graduate Research Fellowship–Honorable Mention (2004)
- American Institute of Chemical Engineers Senior Engineering Prizze, Lehigh University (2003)
- Merck & Co., Inc. Engineering and Technology Fellowship (2001-2002)
- Lehigh University Dean's Scholarship (1999-2003)
- American Association of Immunologists (AAI)
- American Institute of Chemical Engineers (AIChE)
- Biomedical Engineering Society (BMES)
- Controlled Release Society (CRS)
- Society for Biomaterials (SFB)
Books and Chapters
D. J. Irvine and C. M. Jewell, "Vaccine and Immunotherapy Delivery", Comprehensive Biomaterials, Ed. P. Ducheyne, Elsevier Press, 2011, New York, NY.
C. M. Metallo, P. Gameiro, E. Bell, K. Mattaini, J. Yang, K. Hiller, C. M. Jewell, Z. Johnson, D. J. Irvine, L. Guarente, J. K. Kelleher, M. G. Vander Heiden, O. Iliopoulos, and G. Stephanopoulos, "Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia." Nature 2012, 481, 380-384.
C. M. Jewell, S. C. Bustamante López, and D. J. Irvine, "In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles." Proceedings of the National Academy of Sciences USA 2011, 108, 15745-50.
C. M. Jewell*, J. Jung*, P. U. Atukorale, R. P. Carney, F. Stellacci, and D. J. Irvine, "Oligonucleotide delivery by cell-penetrating "striped" nanoparticles." Angewandte Chemie Int. Ed. 2011, 50, 12312-12315.
R. M. Flessner, C. M. Jewell, D. G. Anderson, and D. M. Lynn, "Degradable Polyelectrolyte Multilayers that Promote the Release of siRNA." Langmuir 2011, 27, 7868-7876.
A. S. Breitbach, A.H. Broderick, C. M. Jewell, S. Gunasekaran, Q. Lin, D. M. Lynn, and H. E. Blackwell, "Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity." Chemical Communications 2011, 47, 370-372.
B. Sun, R. M. Flessner, E. M. Saurer, C. M. Jewell, N. J. Fredin, and D. M. Lynn, "Characterization of pH-induced changes in the morphology of polyelectrolyte multilayers assembled from poly(allylamine) and low molecular weight poly(acrylic acid)." Journal of Colloid and Interface Science 2011, 355, 431-441.
N. J. Fredin, R. M. Flessner, C. M. Jewell, S. L. Bechler, M. E. Buck, and D. M. Lynn, "Characterization of nanoscale transformations in polyelectrolyte multilayers fabricated from plasmid DNA using laser scanning confocal microscopy in combination with atomic force microscopy." Microscopy Research and Technique 2010, 73, 834-844.
E. M. Saurer, C. M. Jewell, J. M. Kuchenreuther, D. M. Lynn, "Assembly of Erodible, DNA-Containing Thin Films on the Surfaces of Polymer Microparticles: Toward a Layer-by-Layer Approach to the Delivery of DNA to Antigen-Presenting Cells." Acta Biomaterialia 2009, 5, 913-924.
C. M. Jewell, M. E. Hays, Y. Kondo, N. L. Abbott, and D. M. Lynn, "Chemical Activation of Lipoplexes Formed from DNA and a Redox-Active, Ferrocene-Containing Cationic Lipid." Bioconjugate Chemistry 2008, 19, 2120-2128.
C. M. Jewell and D. M. Lynn, "Surface-Mediated Delivery of DNA: Cationic Polymers Take Charge." Current Opinion in Colloid and Interface Science 2008, 13, 395-402. (review article)
C. M. Jewell and D. M. Lynn, "Multilayered Polyelectrolyte Assemblies as Platforms for the Delivery of DNA and Other Nucleic Acid-Based Therapeutics." Advanced Drug Delivery Reviews 2008, 60, 979-999.
C. L. Pizzey, C. M. Jewell, M. E. Hays, D. M. Lynn, N. L. Abbott, Y. Kondo, S. Golan, and Y. Talmon, "Characterization of the Nanostructure of Complexes formed by a Redox-Active Cationic Lipid and DNA." Journal of Physical Chemistry B 2008, 112, 5849-5857.
M. E. Hays, C. M. Jewell, Y. Kondo, D. M. Lynn, N. L. Abbott, "Lipoplexes Formed by DNA and Ferrocenyl Lipids: Effect of Lipid Oxidation State on Size, Internal Dynamics and Zeta-Potential." Biophysical Journal 2007, 93, 4414-4424.
J. Zhang, S. I. Montañez, C. M. Jewell, D. M. Lynn "Multilayered Films Fabricated from Plasmid DNA and a Side-Chain Functionalized Poly(β-amino ester): Surface-Type Erosion and Sequential Release of Multiple Plasmid Constructs from Surfaces." Langmuir 2007, 23, 11139-11146.
B. Sun, C. M. Jewell, N. J. Fredin, D. M. Lynn, "Assembly of Multilayered Films Using Well-Defined, End-Labeled Poly(acrylic acid): Influence of Molecular Weight on Exponential Growth in a Synthetic Weak Polyelectrolyte System." Langmuir 2007, 23, 8452-8459.
M. E. Hays, C. M. Jewell, D. M. Lynn, N. L. Abbott, "Reversible Condensation of DNA using a Redox-Active Surfactant" Langmuir 2007, 23, 5609-5614.
C. M. Jewell*, S. M. Fuchs*, R. M. Flessner, R. T. Raines, D. M. Lynn, "Multilayered Films Fabricated from an Oligoarginine-Conjugated Protein Promote Efficient Surface-Mediated Protein Transduction." Biomacromolecules 2007, 8, 857-863.
C. M. Jewell, J. Zhang, N. J. Fredin, M. R. Wolff, T. A. Hacker, D. M. Lynn, "Release of Plasmid DNA from Intravascular Stents Coated with Ultrathin Multilayered Polyelectrolyte Films." Biomacromolecules 2006, 7, 2483-2491.
C. M. Jewell, M. E. Hayes, Y. Kondo, N. L. Abbott, D. M. Lynn, "Ferrocene-Containing Cationic Lipids for the Delivery of DNA: Oxidation State Determines Transfection Activity." Journal of Controlled Release 2006, 112, 129-138.
N. L. Abbott, C. M. Jewell, M. E. Hayes, Y. Kondo, D. M. Lynn, "Ferrocene-Containing Cationic Lipids: Influence of Redox States on Cell Transfection." Journal of the American Chemical Society 2005, 127, 11576-11577.
C.M. Jewell, J. Zhang, N. J. Fredin, D.M. Lynn, "Multilayered Polyelectrolyte Films Promote the Direct and Localized Delivery of DNA to Cells." Journal of Controlled Release 2005, 106, 214-223.