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Jewell, Christopher

Jewell, Christopher
Assistant Professor
2212 Jeong H. Kim Engineering Building
Lab Description

News About This Professor

Research Interests 

Vaccine design and immunotherapy, biomaterial interactions with the immune system, autoimmunity, polyelectrolyte multilayers, nanotechnology, polymer and lipid-based drug carriers.


Postdoctoral Fellow, MIT 2009-2012
Ph.D., University of Wisconsin–Madison, 2008

Honors and Awards 

  • Featured in USA Today "New Faces of Engineering" during National Engineers Week (2012)
  • American Association of Immunologists Trainee Award (2012)
  • Burroughs Wellcome Fund Career Award at Scientific Interface– Semifinalist (2012)
  • Controlled Release Society T. Nagai Postdoctoral Research Achievement Award (2011)
  • Ragon Institute of MGH, MIT, and Harvard Science Symposium–Best Poster recipient (2011)
  • Society for Biomaterials STAR award (2011)
  • American Chemical Society Postdoc-to-Faculty Program–Invitee and participant (2010)
  • Ragon Institute of MGH, MIT, and Havard Postdoctoral Fellowship (2009-2011)
  • The Boston Consulting Group Social Impact Fellow–New Zealand conservation work (2008)
  • National Institutes of Health Graduate Student Research Festival–Invitee and presenter (2007)
  • National Science Foundation Graduate Research Fellowship–Honorable Mention (2004)
  • American Institute of Chemical Engineers Senior Engineering Prizze, Lehigh University (2003)
  • Merck & Co., Inc. Engineering and Technology Fellowship (2001-2002)
  • Lehigh University Dean's Scholarship (1999-2003)

Professional Memberships 

  • American Association of Immunologists (AAI)
  • American Institute of Chemical Engineers (AIChE)
  • Biomedical Engineering Society (BMES)
  • Controlled Release Society (CRS)
  • Society for Biomaterials (SFB)

Books and Chapters 

D. J. Irvine and C. M. Jewell, "Vaccine and Immunotherapy Delivery", Comprehensive Biomaterials, Ed. P. Ducheyne, Elsevier Press, 2011, New York, NY.

Selected Publications 

C. M. Metallo, P. Gameiro, E. Bell, K. Mattaini, J. Yang, K. Hiller, C. M. Jewell, Z. Johnson, D. J. Irvine, L. Guarente, J. K. Kelleher, M. G. Vander Heiden, O. Iliopoulos, and G. Stephanopoulos, "Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia." Nature 2012, 481, 380-384.

C. M. Jewell, S. C. Bustamante López, and D. J. Irvine, "In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles." Proceedings of the National Academy of Sciences USA 2011, 108, 15745-50.

C. M. Jewell*, J. Jung*, P. U. Atukorale, R. P. Carney, F. Stellacci, and D. J. Irvine, "Oligonucleotide delivery by cell-penetrating "striped" nanoparticles." Angewandte Chemie Int. Ed. 2011, 50, 12312-12315.

R. M. Flessner, C. M. Jewell, D. G. Anderson, and D. M. Lynn, "Degradable Polyelectrolyte Multilayers that Promote the Release of siRNA." Langmuir 2011, 27, 7868-7876.

A. S. Breitbach, A.H. Broderick, C. M. Jewell, S. Gunasekaran, Q. Lin, D. M. Lynn, and H. E. Blackwell, "Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity." Chemical Communications 2011, 47, 370-372.

B. Sun, R. M. Flessner, E. M. Saurer, C. M. Jewell, N. J. Fredin, and D. M. Lynn, "Characterization of pH-induced changes in the morphology of polyelectrolyte multilayers assembled from poly(allylamine) and low molecular weight poly(acrylic acid)." Journal of Colloid and Interface Science 2011, 355, 431-441.

N. J. Fredin, R. M. Flessner, C. M. Jewell, S. L. Bechler, M. E. Buck, and D. M. Lynn, "Characterization of nanoscale transformations in polyelectrolyte multilayers fabricated from plasmid DNA using laser scanning confocal microscopy in combination with atomic force microscopy." Microscopy Research and Technique 2010, 73, 834-844.

E. M. Saurer, C. M. Jewell, J. M. Kuchenreuther, D. M. Lynn, "Assembly of Erodible, DNA-Containing Thin Films on the Surfaces of Polymer Microparticles: Toward a Layer-by-Layer Approach to the Delivery of DNA to Antigen-Presenting Cells." Acta Biomaterialia 2009, 5, 913-924.

C. M. Jewell, M. E. Hays, Y. Kondo, N. L. Abbott, and D. M. Lynn, "Chemical Activation of Lipoplexes Formed from DNA and a Redox-Active, Ferrocene-Containing Cationic Lipid." Bioconjugate Chemistry 2008, 19, 2120-2128.

C. M. Jewell and D. M. Lynn, "Surface-Mediated Delivery of DNA: Cationic Polymers Take Charge." Current Opinion in Colloid and Interface Science 2008, 13, 395-402. (review article)

C. M. Jewell and D. M. Lynn, "Multilayered Polyelectrolyte Assemblies as Platforms for the Delivery of DNA and Other Nucleic Acid-Based Therapeutics." Advanced Drug Delivery Reviews 2008, 60, 979-999.

C. L. Pizzey, C. M. Jewell, M. E. Hays, D. M. Lynn, N. L. Abbott, Y. Kondo, S. Golan, and Y. Talmon, "Characterization of the Nanostructure of Complexes formed by a Redox-Active Cationic Lipid and DNA." Journal of Physical Chemistry B 2008, 112, 5849-5857.

M. E. Hays, C. M. Jewell, Y. Kondo, D. M. Lynn, N. L. Abbott, "Lipoplexes Formed by DNA and Ferrocenyl Lipids: Effect of Lipid Oxidation State on Size, Internal Dynamics and Zeta-Potential." Biophysical Journal 2007, 93, 4414-4424.

J. Zhang, S. I. Montañez, C. M. Jewell, D. M. Lynn "Multilayered Films Fabricated from Plasmid DNA and a Side-Chain Functionalized Poly(β-amino ester): Surface-Type Erosion and Sequential Release of Multiple Plasmid Constructs from Surfaces." Langmuir 2007, 23, 11139-11146.

B. Sun, C. M. Jewell, N. J. Fredin, D. M. Lynn, "Assembly of Multilayered Films Using Well-Defined, End-Labeled Poly(acrylic acid): Influence of Molecular Weight on Exponential Growth in a Synthetic Weak Polyelectrolyte System." Langmuir 2007, 23, 8452-8459.

M. E. Hays, C. M. Jewell, D. M. Lynn, N. L. Abbott, "Reversible Condensation of DNA using a Redox-Active Surfactant" Langmuir 2007, 23, 5609-5614.

C. M. Jewell*, S. M. Fuchs*, R. M. Flessner, R. T. Raines, D. M. Lynn, "Multilayered Films Fabricated from an Oligoarginine-Conjugated Protein Promote Efficient Surface-Mediated Protein Transduction." Biomacromolecules 2007, 8, 857-863.

C. M. Jewell, J. Zhang, N. J. Fredin, M. R. Wolff, T. A. Hacker, D. M. Lynn, "Release of Plasmid DNA from Intravascular Stents Coated with Ultrathin Multilayered Polyelectrolyte Films." Biomacromolecules 2006, 7, 2483-2491.

C. M. Jewell, M. E. Hayes, Y. Kondo, N. L. Abbott, D. M. Lynn, "Ferrocene-Containing Cationic Lipids for the Delivery of DNA: Oxidation State Determines Transfection Activity." Journal of Controlled Release 2006, 112, 129-138.

N. L. Abbott, C. M. Jewell, M. E. Hayes, Y. Kondo, D. M. Lynn, "Ferrocene-Containing Cationic Lipids: Influence of Redox States on Cell Transfection." Journal of the American Chemical Society 2005, 127, 11576-11577.

C.M. Jewell, J. Zhang, N. J. Fredin, D.M. Lynn, "Multilayered Polyelectrolyte Films Promote the Direct and Localized Delivery of DNA to Cells." Journal of Controlled Release 2005, 106, 214-223.

Related News 

Jewell Lab Makes Strides in Multiple Sclerosis Research
Fischell Department of Bioengineering researchers awarded $599,000 grant from the National Multiple Sclerosis Society. November 17, 2015

BioE Undergrads Celebrate Upcoming 4th Edition of The Catalyst
Department’s first undergraduate research journal highlights student research. September 30, 2015

Andorko Awarded AAPS Graduate Student Fellowship
BioE graduate student recognized for cutting-edge vaccine and drug delivery research. September 21, 2015

Fischell Researchers Develop Innovative Technique to Fine-Tune Vaccines
Members of the Jewell Research Laboratory publish ACS Nano paper on rationally designed vaccines that promote tunable immune responses. June 26, 2015

Fischell Researchers, Wheaton High School Host Second-Annual Symposium to Foster Bioengineering Education
BioE’s Christopher Jewell furthers initiative to expose high school students to new opportunities in bioengineering. June 1, 2015

BioE Capstone 2015: New Projects Focus on Sensorineural Hearing Loss, Injury Rehabilitation, and More
Neonatal acoustic protection device takes first place in annual design competition. May 28, 2015

Invention of the Year Finalist: Intra-Lymph Node Cancer Vaccination Delivery
Jewell develops potent and selective vaccine delivery technique targeting cancer and autoimmune diseases April 1, 2015

UMD To Celebrate Innovations and Partnerships April 29
Nine nominees for Invention of the Year to be recognized at annual event March 23, 2015

Jewell Named ACGT Research Grant Recipient
BioE assistant professor receives prestigious $250,000 Alliance for Cancer Gene Therapy grant. March 16, 2015

UMD Clark School Highlights Disaster Resilience at Mpact Week
Five-day event focused on role of engineers in disaster prevention, mitigation, and response. November 26, 2014

2014 Fischell Festival Tackles Key Topics in Biomedical Emergency Response
Keynote Speaker Rear Admiral Stephen Redd (CDC) discusses Ebola treatment, prevention efforts. October 28, 2014

Tostanoski Receives NSF Graduate Research Fellowship
Ph.D. student Lisa Tostanoski was recently awarded a $132,000 NSF Graduate Research Fellowship. April 14, 2014

Christopher Jewell Receives NSF CAREER Award
Assistant Professor Christopher Jewell Receives NSF CAREER Award for Biomaterial Vaccine Research March 25, 2014

Mukhamedova: HHMI Fellowship Supports System That Could Help Treat MS
BioE junior developing drug delivery system that could help control immune system response. May 8, 2013

Andorko Wins Bioengineering Conference Poster Award
Grad student takes top honors for presentation of "stealthy" drug delivery system. May 2, 2013