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Jay, Steven M.

Jay, Steven M.
Assistant Professor
3234 Jeong H. Kim Engineering Building
Phone: 
301-405-2829
Lab Description

News About This Professor

Research Interests 

Vascular biology and bioengineering, therapeutic vascularization, drug delivery, tissue engineering, exosomal nanotechnology, protein engineering, clinical translation.

Education 

Ph.D., Yale University, 2009

Current Research Projects 

  • Protein engineering for therapeutic vascularization
  • Engineering exosomal nanotechnology for translational therapeutic delivery
  • Enhancing tissue engineering through drug delivery

Honors and Awards 

  • 2012: Innovation in Biotechnology Award – American Association of Pharmaceutical Scientists
  • 2012: NIH K99/R00 Pathway to Independence Award (NHLBI)
  • 2011: Outstanding Abstract – Biomedical Engineering Society (BMES) Fall Meeting
  • 2011: Department of Defense Breast Cancer Postdoctoral Fellowship           
  • 2010: NIH F32 NRSA Postdoctoral Fellowship (declined)
  • 2009: Henry Prentiss Becton Prize (Outstanding Ph.D. Thesis in Engineering) – Yale University

Professional Memberships 

  • Biomedical Engineering Society (BMES)
  • American Association of Pharmaceutical Scientists (AAPS)
  • International Society of Applied Cardiovascular Biology (ISACB)
  • Controlled Release Society (CRS)

Selected Publications 

Park J; Wrzesinski SH; Stern E; Look M; Jay SM; Demento SL; Agawu A; Limon PL; Ferrandino AF; Flavell RA; Fahmy TM (2012). Enhanced anti-tumor activity by combination immunotherapy with sustained release of IL-2 and a TGF-β inhibitor from nanolipogel vehicles. In press in Nature Materials. 

Jay SM; Kurtagic E; Alvarez LM; de Picciotto S; Sanchez E; Hawkins JF; Prince RN; Guerrero Y; Treasure CT; Lee RT; Griffith LG (2011). Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. Journal of Biological Chemistry 286(31):27729-40. Selected by Faculty of 1000.

Jay SM; Shepherd BR; Andrejecsk JW; Kyriakides TR; Pober JS; Saltzman WM (2010). Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials 31(11):3054-3062. Featured in Science Translational Medicine, 17 March 2010:Vol. 2, Issue 23, p. 23ec45. Editors' Choice: Protein Cocktail Nourishes New Vessels.

Roh JD; Sawh-Martinez R; Brennan MP; Jay SM; Devine L; Yi T; Mirensky T; Rao DA; Udelsman B; Nelson GN; Hibino N; Shinoka T; Saltzman WM; Snyder E; Kyriakides TR; Pober JS; Breuer CK. (2010) Human Bone Marrow Cell Seeding Improves Outcomes of Tissue-Engineered Vascular Grafts through MCP-1 Mediated Monocyte Recruitment. PNAS 107(10):4669-74.

Stern E; Jay SM; Demento S; Murelli R; Reed MA; Malinski T; Spiegel D; Mooney DJ; Fahmy TM. (2009) Spatiotemporal control over molecular delivery and cellular encapsulation from electropolymerized micro- and nanopatterned surfaces. Advanced Functional Materials 19(18):2888-2895.

Jay SM; Saltzman WM. (2009) Controlled Delivery of VEGF Via Modulation of Alginate Microparticle Ionic Crosslinking. Journal of Controlled Release 134(1):26-34.

Shepherd BR; Jay SM; Saltzman WM; Tellides G; Pober JS. (2009) Accelerated Synthetic Microvessel Remodeling by Co-Engraftment of Human Endothelial Cells and Vascular Smooth Muscle Cells. Tissue Engineering Part A 15(1):165-173. Featured in Advances in Tissue Engineering, Volume 1: Angiogenesis (2009), Peter C. Johnson and Antonios G. Mikos, eds.

Jay SM; Shepherd BR; Bertram JP; Pober JS; Saltzman WM. (2008) Engineering of Multifunctional Gels Integrating Highly Efficient Growth Factor Delivery with Endothelial Cell Transplantation. FASEB Journal 22(8):2949-56.

Jay SM; Skokos E; Laiwalla F; Krady M; Kyriakides TR. (2007) Foreign Body Giant Cell Formation Is Preceded by Lamellipodia Formation and Can Be Attenuated by Inhibition of Rac1 Activation. Am. J. Pathol. 171:2:632-40.

Jay S; Fountain W; Cui Z; Mumper RJ. (2002) Transmucosal Delivery of Testosterone in Rabbits Using Novel Bi-Layer Mucoadhesive Wax-Film Composite Disks. Journal of Pharmaceutical Science 91:2016-2025.

Selected Presentations 

Sanchez-Palacios EI; Sears D; Jay SM; White FM; Griffith LG. The Role of c-MET and Her-3 Receptor Crosstalk in HGF-induced Cell Migration in NSCLC and Breast Tumor Cells. Presentation at Biomedical Engineering Society (BMES) Annual Meeting, Atlanta, GA, October 24-27, 2012.

Jay SM; Hawkins JF; Murthy AC; Wortzel JR; Griffith LG; Lee RT. Protein Engineering to Access Preferred ErbB Signaling Pathways for Cardiovascular Therapy. Oral and Poster Presentations at MIT Cell Decision Process Retreat, Cambridge, MA, June 22, 2012.

Jay SM; Hawkins JF; Murthy AC; Wortzel JR; Griffith LG; Lee RT. Protein Engineering to Access Preferred ErbB Signaling Pathways for Cardiovascular Therapy. Oral and Poster Presentations at AAPS National Biotechnology Conference, San Diego, CA, May 21-23, 2012. Innovation in Biotechnology Award Winner

Jay SM; Hawkins JF; Kurtagic E; Griffith LG; Lee RT. Directing Receptor Interactions via Protein Engineering: Towards Enhanced Cardioprotective Therapy. Oral Presentation at Biomedical Engineering Society (BMES) Annual Meeting, Hartford, CT, October 12-15, 2011. Outstanding Abstract Recognition

Jay SM; Griffith LG; Lee RT. Engineering Neuregulin to Bias ErbB Signaling for Enhanced Cardiovascular Therapy.  Poster presentation at 12th Biennial Meeting of International Society for Applied Cardiovascular Biology (ISACB), Cambridge, MA, September 22-25, 2010.

For a complete list, please visit Professor Jay's web site »

Related News 

BioE Capstone 2016: New Projects Focus on Improved Healthcare for Underserved Communities, Pediatric Patients, and More
Affordable RT-PCR for clinical diagnostics, fear mitigation device for pediatric MRIs tie for first place. June 28, 2016

Jay Lab Works Toward Engineering Extracellular Vesicles as Next-Generation Biotherapeutics
BioE assistant professor receives 2015 Ralph E. Powe Junior Faculty Enhancement Award. January 21, 2016

Schardt Awarded UMD-NCI Cancer Research Training Fellowship
BioE graduate student recognized for efforts to develop novel molecular engineering approach to breast and ovarian cancer therapy.  September 18, 2015