Jay, Steven M.
Vascular biology and bioengineering, therapeutic vascularization, drug delivery, tissue engineering, exosomal nanotechnology, protein engineering, clinical translation.
Ph.D., Yale University, 2009
Current Research Projects
- Protein engineering for therapeutic vascularization
- Engineering exosomal nanotechnology for translational therapeutic delivery
- Enhancing tissue engineering through drug delivery
Honors and Awards
- 2012: Innovation in Biotechnology Award – American Association of Pharmaceutical Scientists
- 2012: NIH K99/R00 Pathway to Independence Award (NHLBI)
- 2011: Outstanding Abstract – Biomedical Engineering Society (BMES) Fall Meeting
- 2011: Department of Defense Breast Cancer Postdoctoral Fellowship
- 2010: NIH F32 NRSA Postdoctoral Fellowship (declined)
- 2009: Henry Prentiss Becton Prize (Outstanding Ph.D. Thesis in Engineering) – Yale University
- Biomedical Engineering Society (BMES)
- American Association of Pharmaceutical Scientists (AAPS)
- International Society of Applied Cardiovascular Biology (ISACB)
- Controlled Release Society (CRS)
Park J; Wrzesinski SH; Stern E; Look M; Jay SM; Demento SL; Agawu A; Limon PL; Ferrandino AF; Flavell RA; Fahmy TM (2012). Enhanced anti-tumor activity by combination immunotherapy with sustained release of IL-2 and a TGF-β inhibitor from nanolipogel vehicles. In press in Nature Materials.
Jay SM; Kurtagic E; Alvarez LM; de Picciotto S; Sanchez E; Hawkins JF; Prince RN; Guerrero Y; Treasure CT; Lee RT; Griffith LG (2011). Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. Journal of Biological Chemistry 286(31):27729-40. Selected by Faculty of 1000.
Jay SM; Shepherd BR; Andrejecsk JW; Kyriakides TR; Pober JS; Saltzman WM (2010). Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials 31(11):3054-3062. Featured in Science Translational Medicine, 17 March 2010:Vol. 2, Issue 23, p. 23ec45. Editors' Choice: Protein Cocktail Nourishes New Vessels.
Roh JD; Sawh-Martinez R; Brennan MP; Jay SM; Devine L; Yi T; Mirensky T; Rao DA; Udelsman B; Nelson GN; Hibino N; Shinoka T; Saltzman WM; Snyder E; Kyriakides TR; Pober JS; Breuer CK. (2010) Human Bone Marrow Cell Seeding Improves Outcomes of Tissue-Engineered Vascular Grafts through MCP-1 Mediated Monocyte Recruitment. PNAS 107(10):4669-74.
Stern E; Jay SM; Demento S; Murelli R; Reed MA; Malinski T; Spiegel D; Mooney DJ; Fahmy TM. (2009) Spatiotemporal control over molecular delivery and cellular encapsulation from electropolymerized micro- and nanopatterned surfaces. Advanced Functional Materials 19(18):2888-2895.
Jay SM; Saltzman WM. (2009) Controlled Delivery of VEGF Via Modulation of Alginate Microparticle Ionic Crosslinking. Journal of Controlled Release 134(1):26-34.
Shepherd BR; Jay SM; Saltzman WM; Tellides G; Pober JS. (2009) Accelerated Synthetic Microvessel Remodeling by Co-Engraftment of Human Endothelial Cells and Vascular Smooth Muscle Cells. Tissue Engineering Part A 15(1):165-173. Featured in Advances in Tissue Engineering, Volume 1: Angiogenesis (2009), Peter C. Johnson and Antonios G. Mikos, eds.
Jay SM; Shepherd BR; Bertram JP; Pober JS; Saltzman WM. (2008) Engineering of Multifunctional Gels Integrating Highly Efficient Growth Factor Delivery with Endothelial Cell Transplantation. FASEB Journal 22(8):2949-56.
Jay SM; Skokos E; Laiwalla F; Krady M; Kyriakides TR. (2007) Foreign Body Giant Cell Formation Is Preceded by Lamellipodia Formation and Can Be Attenuated by Inhibition of Rac1 Activation. Am. J. Pathol. 171:2:632-40.
Jay S; Fountain W; Cui Z; Mumper RJ. (2002) Transmucosal Delivery of Testosterone in Rabbits Using Novel Bi-Layer Mucoadhesive Wax-Film Composite Disks. Journal of Pharmaceutical Science 91:2016-2025.
Sanchez-Palacios EI; Sears D; Jay SM; White FM; Griffith LG. The Role of c-MET and Her-3 Receptor Crosstalk in HGF-induced Cell Migration in NSCLC and Breast Tumor Cells. Presentation at Biomedical Engineering Society (BMES) Annual Meeting, Atlanta, GA, October 24-27, 2012.
Jay SM; Hawkins JF; Murthy AC; Wortzel JR; Griffith LG; Lee RT. Protein Engineering to Access Preferred ErbB Signaling Pathways for Cardiovascular Therapy. Oral and Poster Presentations at MIT Cell Decision Process Retreat, Cambridge, MA, June 22, 2012.
Jay SM; Hawkins JF; Murthy AC; Wortzel JR; Griffith LG; Lee RT. Protein Engineering to Access Preferred ErbB Signaling Pathways for Cardiovascular Therapy. Oral and Poster Presentations at AAPS National Biotechnology Conference, San Diego, CA, May 21-23, 2012. Innovation in Biotechnology Award Winner
Jay SM; Hawkins JF; Kurtagic E; Griffith LG; Lee RT. Directing Receptor Interactions via Protein Engineering: Towards Enhanced Cardioprotective Therapy. Oral Presentation at Biomedical Engineering Society (BMES) Annual Meeting, Hartford, CT, October 12-15, 2011. Outstanding Abstract Recognition
Jay SM; Griffith LG; Lee RT. Engineering Neuregulin to Bias ErbB Signaling for Enhanced Cardiovascular Therapy. Poster presentation at 12th Biennial Meeting of International Society for Applied Cardiovascular Biology (ISACB), Cambridge, MA, September 22-25, 2010.
For a complete list, please visit Professor Jay's web site »