BioE Home
Return to Faculty Directory »  |  Return to Laboratories »

Herold, Keith

Keith Herold
Associate Professor
Director, M.Eng. Program in Bioengineering
3236 Jeong H. Kim Engineering Building
Phone: 
301-405-5268
Fax: 
301-405-9953
Lab Description

News About This Professor


Research Interests 

BioMEMS; microfluidic systems for bioanalytical assays; heat and mass transfer in bioengineering

Education 

Ph.D., Ohio State University, 1985

Background 

Associate Professor Keith Herold joined the University of Maryland's Department of Mechanical Engineering in 1987, where his research focused on energy systems and absorption refrigeration. In 2000, he shifted his focus to bioengineering and began exploring biosensors, microarrays, and related lab-on-a-chip technologies. In 2006 he joined the newly formed Fischell Department of Bioengineering, where his work in these areas continues. His current research projects include collaborations with the FDA on a DNA-based pathogen biosensor, and with electrophysiologists at the University of Maryland School of Medicine on the analysis of patients suffering from ventricular tachycardia.

Honors and Awards 

  • Fellow, American Society of Mechanical Engineers

Books and Chapters 

Series in Sensors: Biosensors and Molecular Technologies for Cancer Diagnostics, K.E. Herold and Avraham Rasooly, editors, CRC Press 2012.

Biosensors and Biodetection: Methods and Protocols, Volume 1: Optical-Based Detectors and Biosensors and Biodetection: Methods and Protocols, Volume 2: Electrochemical and Mechanical Detectors, Lateral Flow and Ligands for Biosensors, K.E. Herold and Avraham Rasooly, editors, Springer, 2009.

Natural Gas-Fired Cooling Technologies and Economics, K.E. Herold, E. de los Reyes, L. Harriman, D.V. Punwani, W.A. Ryan, Gas Technology Institute, 2005, 286 pages, www.gastechnology.org.

Absorption Chillers and Heat Pumps, K.E. Herold, R. Radermacher and S.A. Klein, CRC Press, 1996, 350 pages, original edition.

Herold, K.E., 2009, “A Simple Portable Electroluminescence Illumination Based CCD Detector,” in Biosensors and Biodetection: Methods and Protocols, Volume 1: Optical-Based Detectors and Biosensors, Springer.

Herold, K.E., 2009, “Rapid DNA Amplification Using a Battery-powered Thin-Film Resistive Thermocycler (TFRT)” in Biosensors and Biodetection: Methods and Protocols, Volume 2: Electrochemical and Mechanical Detectors, Lateral Flow and Ligands for Biosensors,Springer.

Rasooly, A., Herold, K.E., 2008, "Application of DNA Microarray Technology for Microbial Analysis", chapter 6 in Nano and Microsensors for Chemical and Biological Terrorism Surveillance, edited by J. B.-H. Tok, Royal Society of Chemistry, galley proof stage, pp. 111-151.

Herold, K.E., Rasooly, A., 2008, "Oligonucleotides as Recognition and Catalytic Elements", chapter in book edited by Mahmmad Zourob, submitted.

Herold, K.E., and Rasooly, A., 2008, "PCR paper ****", chapter in Biosensors, a volume in the series Methods in Molecular Biology, Humana Press, submitted.

Kostov, Y., Sergeev, N., Wilson, S., Herold, K.E., and Rasooly, A., 2008, "A simple portable electroluminescence illumination based CCD detector", chapter in Biosensors, a volume in the series Methods in Molecular Biology, Humana Press, submitted.

Sergeev, N., Herold, K.E., Rasooly., A,  2007, "Regulatory and validation issues for biosensors and related bioanalytical technologies", Chapter 86  in Handbook of Biosensors and Biochips, John Wiley & Sons Ltd Publishers, Vo2. 2, pp. 1289-1303.

Herold,K.E., 2007, "Absorption Heat Pumps for Waste Heat Recovery Applications ", chapter in Encyclopedia of Energy Engineering and Technology,  edited by Barney Capehart, Taylor and Francis, Vol. 3, pp. 1541-1547.

Al-Khaldi, S.F., Mossoba, M.M., Myers, K., Herold, K.E., Hart, S.J., and Terray, A., 2006, "Using Micro- and Nano- Technology in Bacterial Isolation and Identification from Complex Food Matrices", Chapter 6 in New Developments in Nutrition Research, NOVA Science Publishers, pp. 135-167.

Sergeev, N., Herold, K.E., Rasooly, A., 2006, "Microarray Analysis of Microbial Pathogens", Chapter 17 in Encyclopedia of Rapid Microbiological Methods, Vol. 3, pp. 363-405.

Rasooly, A., Herold, K.E., 2006, "Biosensors for Microbial Diagnostics", Chapter 18 in Encyclopedia of Rapid Microbiological Methods, Vol. 3, pp. 407-448.

Sergeev, N., Rasooly, A., Herold, K.E., 2005, "Oligonucleotide Design For PCR Primers And Microarray Probes", chapter in Encyclopedia of Medical Genomics and Proteomics, Vol. 2, pp. 938-942.

Herold, K.E., "Heat Transfer", Chapter 12 in An Engineer’s Guide to Matlab, Prentice Hall, 2000, pp. 517-570, second edition 2005, pp. 554-602.

Selected Publications 

Rasooly, A., Herold, K.E., 2008, "Food microbial pathogen detection and analysis using DNA microarray technologies", Foodborne Pathogens and Disease, 2nd revision submitted May 08.

Rasooly, A., Sergeev, N., Herold, K.E., 2007, "Biosensor technologies for microbial and environmental analysis", Minerva Biotecnologica, Vo. 19, No. 3, pp. 105-116.

Kyung, I.-S., Herold, K.E., Kang, Y. T., 2007 , "Experimental verification of H2O/LiBr absorber bundle performance with smooth horizontal tubes", Int. J. Refrigeration, Vol. 30, pp. 582-590.

Kyung, I.-S., Herold, K.E., Kang, Y. T., 2007, "Model for absorption of water vapor into aqueous LiBr flowing over a horizontal smooth tube", Int. J. Refrigeration, Vol. 30, pp. 591-600.

Rasooly, A., Herold, K.E., 2006, "Biosensors for the Analysis of Food and Water Borne Pathogens and their Toxins", J. of AOAC International, Vol. 89, No. 3, pp. 873-883.

Yuan, Z., Herold, K.E., 2005, "Specific Heat Measurements on Aqueous Lithium Bromide", International J. Heating, Ventilating, Air-Conditioning and Refrigeration, Vol. 11, No. 3, pp. 361-375.

Yuan, Z., Herold, K.E., 2005, "Thermodynamic Properties of Aqueous Lithium Bromide Using a Multiproperty Free Energy Correlation", International J. Heating, Ventilating, Air-Conditioning and Refrigeration, Vol. 11, No. 3, pp. 377-393.

Herold, K.E., Rasooly, A., 2003, "Oligo Design, A Computer Program for Development of Probes for Oligonucleotide Microarrays", BioTechniques, Vol. 35, No. 6, pp. 1216-1218,1220-1221.

Buran, B., Butler, L., Currano, A., Smith, E., Tung, W., Cleveland, K., Buxton, C., Lam, D., Obler, T., Rais-Bahrami, S., Stryker, M., Herold, K.E., 2003, "Environmental Benefits of Implementing Alternative Energy Technologies in Developing Countries", Applied Energy, Vol. 76, Issues 1-3, pp. 89-100.

Zhou, X., Yuan, Z., Herold, K.E., 2001, "Phase Distribution of the Surfactant 2-Ethyl-Hexanol in Aqueous Lithium Bromide", International J. Heating, Ventilating, Air-Conditioning and Refrigeration, Vol. 8, No. 4, pp. 371-381.

Ghosh, K., Zhou, X., Herold, K.E., 2002, "Circulation of 2-Ethyl-Hexanol in an Absorption Chiller", ASHRAE Transactions, Vol. 108, Pt. 1, pp. 861-866.

Kyung, I.-S., Herold, K.E., "Performance of a Horizontal Smooth Tube Absorber with and without 2-Ethyl-Hexanol", Journal of Heat Transfer, Vol. 124, pp. 177-183, February 2002.

Yuan, Z.,  Herold, K.E.,  "Surface Tension of Aqueous Lithium Bromide with Controlled Vapor Concentration of 2-ethyl-hexanol", ASHRAE Transactions, Vol. 107, Part 1, pp. 463-468, 2001.

Yuan, Z.,  Herold, K.E., "Surface Tension of Pure Water and Aqueous Lithium Bromide with 2-ethyl-hexanol", Applied Thermal Engineering, Vol. 21, No. 8, pp. 881-897, June 2001.

Kulankara, S. Herold, K.E., "Surface Tension of Aqueous Lithium Bromide with Heat/Mass Transfer Additives", Int. J. Refrigeration, Vol. 25, Issue 3,pp. 383-389, 2002.

Kulankara, S., Herold, K.E., "Theory of Heat/Mass Transfer Additives in Absorption Chillers", ASHRAE Transactions, Vol. 107, Pt. 1, pp. 305-315, 2001.

Kulankara, S., Herold, K.E., "Theory of Heat/Mass Transfer Additives in Absorption Chillers", International J. Heating, Ventilating, Air-Conditioning and Refrigeration Research, Vol. 6, No. 4, pp. 369-380, October 2000.http://www.gastechnology.org/Pages/default.aspx

Related News 

BIOE Capstone 2017: Projects Focus on Pediatric Care, Physical Therapy, Pulmonary Tumors, and More
BIOE hosted it's largest-ever Capstone Design competition on May 10th, 2017. May 17, 2017

BioE Capstone 2016: New Projects Focus on Improved Healthcare for Underserved Communities, Pediatric Patients, and More
Affordable RT-PCR for clinical diagnostics, fear mitigation device for pediatric MRIs tie for first place. June 28, 2016

BioE Capstone 2015: New Projects Focus on Sensorineural Hearing Loss, Injury Rehabilitation, and More
Neonatal acoustic protection device takes first place in annual design competition. May 28, 2015

UMD to Launch Graduate Certificate in Regulatory Science and Engineering This Fall
Twelve-credit program will focus on medical device engineering and regulation. July 23, 2014

BioE Capstone 2013: New Products Focus on Diagnostics, Physical Therapy and More
Students' inventions address needs ranging from home care to ICU. July 11, 2013

2012-2013 Round 1 Exchange Awards Winners
UM-CERSI announces the 2012-2013 winners of round 1 Exchange Award  January 10, 2013

Herold Co-Edits New Book on Cancer Diagnostics
Biosensors and Molecular Technologies for Cancer Diagnostics released by CRC Press. October 2, 2012

University of Maryland Wins 2011 Solar Decathlon
Campus-wide effort key to WaterShed victory in international competition. October 2, 2011

Herold Helps Solar House Team Shine
BioE professor serves as the Engineering Faculty Advisor to WaterShed in Solar Decathlon competition. September 28, 2011

Inoue Joins BioE as Professor of the Practice
Canon U.S. Life Sciences senior fellow developing system for rapid diagnosis of disease. August 4, 2011

Canon U.S. Life Sciences and the University of Maryland Launch New Collaboration
Joint team to develop automated machine designed to expedite the diagnosis of infectious diseases. July 19, 2011

Capstone 2011: Improved Diagnostics and Monitoring, Surgical Devices, and Personal Technology
Learn about new products from tomorrow's innovators. June 2, 2011

BioE Hosts 26th Southern Biomedical Engineering Conference
Attendees share emerging research on human health. May 5, 2010

Herold Edits 2 Vol. Book on Biosensors, Biodetection
Titles part of Methods in Molecular Biology series. January 9, 2009

Herold Lectures in Taiwan
Professor invited to universities, research institute. June 18, 2008

Projects Come Together at Capstone II
Seniors show the results of a year's work. June 5, 2007

Students Impress At Capstone I Wrap-Up
Presentations showcase a semester of ideas, research. December 18, 2006