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Chen, Yu

Yu Chen
Associate Professor
2218 Jeong H. Kim Engineering Building
Lab Description

News About This Professor

Research Interests 

Biomedical optical imaging, optical coherence tomography (OCT), multi-photon Microsopy (MPM), diffuse optical spectroscopy and imaging, molecular imaging, early cancer diagnosis, neuroimaging.


Ph.D., University of Pennsylvania, 2003

Honors and Awards 

  • 2013: NSF CAREER Award
  • 2011: Fellow, American Society of Lasers in Medicine and Surgery
  • 2010: Robert E. Fischell Teaching Excellence Award
    (Fischell Department of Bioengineering, University of Maryland, College Park)
  • 2006: Outstanding Instrumentation Research Paper of 2005
    (Biomedical Instrumentation and Technology)
  • 2004–2006: Postdoctoral Fellowship
    (Cancer Research and Prevention Foundation)
  • 2003: Finalist – Young Investigator Competition
    (Association for the Advancement of Medical Instrumentation and Whitaker Foundation)
  • 2003: Solomon R. Pollack Award for Excellence in Graduate Bioengineering  Research
    (University of Pennsylvania)
  • 2002: Poster Award
    (28th Annual Northeast Bioengineering Conference, IEEE Engineering in Medicine and Biology Society)
  • 2000: Student Fellowship
    (Education Foundation, Society of Nuclear Medicine)

Professional Memberships 

  • American Society of Lasers in Medicine and Surgery
  • Optical Society of America (OSA)
  • International Society for Optical Engineering (SPIE)
  • Institute of Electrical and Electronics Engineers (IEEE)
  • Biomedical Engineering Society (BMES)
  • American Association for the Advancement of Science (AAAS)
  • Sigma Xi

Books and Chapters 

Y. Chen, E. Bousie, C. Pitris, J.G. Fujimoto, "Optical Coherence Tomography: Introduction and Theory," in Handbook of Biomedical Optics, D.A. Boas, C. Pitris, N. Ramanujam, Eds., Taylor & Francis Books (in press).

S. Yuan, Y. Chen*, "Optical Coherence Tomography Based Multi-Modal Optical Imaging in Biomedical Applications," in Advances in Lasers and Electro Optics, V. Kordic, Ed., IN-TECH (in press).

Y. Chen, A.D. Aguirre, D. Adler, H. Mashimo, J.G. Fujimoto, "Endoscopy," in Translational Multimodality Optical Imaging, X. Intes, F. Azar, Eds., Artech House (2008).

W. Drexler, Y. Chen, A. Aguirre, B. Povazay, A. Unterhuber, J.G. Fujimoto, "Ultrahigh Resolution Optical Coherence Tomography," in Optical Coherence Tomography: Technology and Applications, J.G. Fujimoto and W. Drexler, Eds., Springer (2008).

A. Unterhuber, B. Povazay, A. Aguirre, Y. Chen, F.X. Kartner, J.G. Fujimoto, W. Drexler, "Broad Bandwidth Laser and Nonlinear Optical Light Sources for OCT," in Optical Coherence Tomography: Technology and Applications, J.G. Fujimoto and W. Drexler, Eds., Springer (2008).

J.G. Fujimoto, Y. Chen, A. Aguirre, "Biomedical Imaging using Optical Coherence Tomography," in Biomedical Optics Handbook, Oxford University Press (2008).

J.G. Fujimoto, A. Aguirre, Y. Chen, P. Herz, P. Hsiung, T. Ko, N. Nishizawa, F. Kaertner, "Ultrahigh Resolution Optical Coherence Tomography using Femtosecond Lasers," in Ultrashort Laser Pulse in Biology and Medicine, M. Braun, P. Gilch, W. Zinth, Eds., Springer (2007).

Selected Publications 

R. M. Lovering*, S.B. Shah, S.J.P. Pratt, W. Gong, Y. Chen, “Architecture of Healthy and Dystrophic Muscles Detected by Optical Coherence Tomography,” Muscle and Nerve, 47, 588-590 (2013).
Y. Chen*, H. Guo, W. Gong, L. Qin, H. Aleyasin, R.R. Ratan, S. Cho, J. Chen, S. Xie, “Recent Advances in Two-Photon Imaging: Technology Developments and Biomedical Applications,” Chinese Optics Letters, 11, 011703 (2013).
C.P. Liang, B. Yang, I.K. Kim, G. Makris, J.P. Desai, R.P. Gullapalli, Y. Chen*, “Concurrent Multiscale Imaging with Magnetic Resonance Imaging and Optical Coherence Tomography,” Journal of Biomedical Optics, 18, 046015 (2013).
C.P. Liang, Y. Wu, J. Schmitt, P.E. Bigeleisen, J. Slavin, M.S. Jafri, C.M. Tang, Y. Chen*, “Coherence-gated Doppler: a Fiber Sensor for Precise Localization of Blood Flow,” Biomedical Optics Express, 4, 760-771 (2013).
A. Agrawal*, C.W. Chen, J. Baxi, Y. Chen, T. J. Pfefer, “Multilayer thin-film phantoms for axial contrast transfer function measurement in optical coherence tomography,” Biomedical Optics Express, 4, 1166-1175 (2013).

A. Agrawal, M. Connors, A. Beylin, C.P. Liang, D. Barton, Y. Chen, R.A. Drezek, T.J. Pfefer*, "Characterizing the Point Spread Function of Retinal OCT Systems with a Model Eye-Based Phantom," Biomedical Optics Express, 3, 1116-1126 (2012).

E. Ayvali, C.P. Liang, Y. Chen, J. Desai*, "A Discretely Actuated Steerable Cannula with Integrated Optical Coherence Tomography (OCT) Imaging," International Journal of Robotics Research, 31, 588-603 (2012).

Y. Chen, C.P. Liang, Y. Liu, A.V. Parwani, A.H. Fischer, L. Pantanowitz*, "Review of Advanced Imaging Techniques", Journal of Pathological Informatics, 3, 22 (2012).

C.P. Liang, C.W. Chen, J. Desai, R. Gullapalli, C.M. Tang, R. Mezrich, Y. Chen*, "Endoscopic Microscopy Using Optical Coherence Tomography," Current Medical Imaging Reviews, in press.

Y. Chen*, S.W. Huang, C. Zhou, B. Potsaid, J.G. Fujimoto, "Improved Detection Sensitivity of Line-Scanning Optical Coherence Microscopy," IEEE Journal of Selected Topics in Quantum Electronics, 18, 1094-1099 (2012).

C.P. Liang, J. Wierwille, T. Moreira, G. Schwartzbauer, M.S. Jafri, C.M. Tang, Y. Chen*, "A Forward-Imaging Needle-Type OCT Probe for Image Guided Stereotactic Procedures," Optics Express, 19, 26283-26294 (2011).

J. Wierwille, P.M. Andrews, M. Onozato, J. Jiang, A. Cable, Y. Chen*, "In vivo, label-free, three-dimensional quantitative imaging of kidney microcirculation using Doppler optical coherence tomography (DOCT)," Laboratory Investigation, 91, 1596-1604 (2011).

C.W. Chen, Y. Chen*, "Optimization of Design Parameters for Fluorescence Laminar Optical Tomography," Journal of Innovation in Optical Health Sciences, 4, 309-323 (2011).

C.W. Chen, M.W. Betz, J.P. Fisher, A. Paek, Y. Chen*, "Macroporous Hydrogel Scaffolds and Their Characterization By Optical Coherence Tomography," Tissue Engineering–Part C: Methods, in press.

C.A. Roney, B. Xu, J. Xie, S. Yuan, J. Wierwille, C.W. Chen, Y. Chen, G.L. Griffiths, M. Kono, R. Proia, R.M. Summers*, "Rh-I-UEA-1 polymerized liposomes target and image adenomatous polyps in the APCMin/+ mouse using optical colonography," Molecular Imaging, in press.

K.A. DiVito, V.A. Trabosh, Y.S. Chen, C. Albanese, Y. Chen, A. Mauviel, C.M. Simbulan-Rosenthal, D.S. Rosenthal*, "Smad7 Suppresses N-cadherin Cleavage in Metastatic Melanoma Through β-catenin Stabilization and Restores Heterotypic Cell-Cell Interactions In Vivo," Pigment Cell & Melanoma Research, in press.

Y. Chen*, S. Yuan, J. Wierwille, R. Naphas, Q. Li, T. Blackwell, P. Winnard, V. Raman, K. Glunde, "Integrated Optical Coherence Tomography (OCT) with Fluorescence Laminar Optical Tomography (FLOT)," IEEE Journal of Selected Topics in Quantum Electronics, 16, 755-766 (2010). (Invited Paper)

A.D. Aguirre, Y. Chen, B. Bryan, H. Mashimo, Q. Huang, J.L. Connolly, J.G. Fujimoto*, "Cellular Resolution Ex Vivo Imaging of Gastrointestinal Tissues with Optical Coherence Microscopy," Journal of Biomedical Optics, 15, 016025 (2010).

S. Yuan, C.A. Roney, J. Wierwille, C.W. Chen, B. Xu, G. Griffiths, J. Jiang, H. Ma, A. Cable, R.M. Summers, Y. Chen*, "Co-registered Optical Coherence Tomography and Fluorescence Molecular Imaging for Simultaneous Morphological and Molecular Imaging," Physics in Medicine and Biology, 55, 191-206 (2010).

M.L. Onozato, P.M. Andrews, Q. Li, J. Jiang, A. Cable, Y. Chen*, "Optical Coherence Tomography Imaging of Intact Human Kidney Ex-Vivo," Journal of Urology, 183, 2090-2094 (2010).

C.W. Chen, T. Blackwell, R. Naphas, K. Glunde, Y. Chen*, "Development of Needle-Based Microendoscopy for Fluorescence Molecular Imaging of Breast Tumor (Invited Paper)," Journal of Innovation in Optical Health Sciences, 2, 343-352 (2009).

Q. Li, M.L. Onozato, P.M. Andrews, C.W. Chen, A. Paek, R. Naphas, S. Yuan, J. Jiang, A. Cable, Y. Chen*, "Automated Image Analysis of Three-Dimensional Microstructures of the Human Kidney using Optical Coherence Tomography (OCT)," Optics Express, 17, 16000-16016 (2009). (Also featured on OCT News »)

S. Yuan, Q. Li, J. Jiang, A. Cable, Y. Chen*, "Three-Dimensional Co-Registered Optical Coherence Tomography and Line-Scanning Fluorescence Laminar Tomography," Optics Letters, 34, 1615-1617 (2009).

Y. Chen, A.D. Aguirre, L. Ruvinskaya, A. Devor, D.A. Boas, J.G. Fujimoto, "Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation", Journal of Neuroscience Methods, 178, 162–173 (2009).

Y. Chen, A.D. Aguirre, P. Hsiung, S. Huang, H. Mashimo, S. Desai, J. Schmitt, J.G. Fujimoto, "Comparison of Ultrahigh and Standard Resolution Endoscopic Optical Coherence Tomography for Gastrointestinal Imaging," Optics Express, 16, 2469-2485 (2008).

P.M. Andrews, Y. Chen, S. Huang, D. Adler, R. Huber, J. Jiang, S. Barry, A. Cable, J.G. Fujimoto, "High-Speed Three-Dimensional Optical Coherence Tomography Imaging of Kidney Ischemia In Vivo," Laboratory Investigation, 88, 441-449 (2008).

D. Adler, Y. Chen, R. Huber, J.M. Schmitt, J. Connolly, J.G. Fujimoto, "Three-Dimensional Endomicroscopy with Optical Coherence Tomography," Nature Photonics, 1, 709-176 (2007).

P. Hsiung, D. Phatak, Y. Chen, A.D. Aguirre, L. Pantanowitz, J.G. Fujimoto, J.L. Connolly, "Ultrahigh Resolution and 3D Optical Coherence Tomography Ex Vivo Imaging of Malignant and Benign Lesions in Human Breast," Radiology, 244, 865-874 (2007).

Y. Chen, S. Huang, A.D. Aguirre, J.G. Fujimoto, "High-Resolution Line-Scanning Optical Coherence Microscopy," Optics Letters, 32, 1971-1973 (2007).

Y. Chen, A.D. Aguirre, P. Hsiung, S. Desai, P.R. Herz, M. Pedrosa, Q. Huang, M. Figueiredo, S. Huang, A. Koski, J.M. Schmitt, J.G. Fujimoto, H. Mashimo, "Ultrahigh Resolution Optical Coherence Tomography of Barrett’s Esophagus – Preliminary Descriptive Clinical Study Correlating Images with Histology," Endoscopy, 39, 599-605 (2007).  (Featured on the Journal Cover)

Y. Chen, P.M. Andrews, A.D. Aguirre, J.M. Schmitt, J.G. Fujimoto, "High-Resolution Three-Dimensional Optical Coherence Tomography Imaging of Kidney Microanatomy Ex Vivo," Journal of Biomedical Optics, 12, 034008 (2007).

A.D. Aguirre, Y. Chen, L. Ruvinskaya, A. Devor, D.A. Boas, J.G. Fujimoto, "Cross-sectional Imaging of Functional Activation in the Rat Somatosensory Cortex with Optical Coherence Tomography," Optics Letters, 31, 3459-3461 (2006).

P. Hsiung, L. Pantanowitz, A.D. Aguirre, Y. Chen, D. Phatak, J.L. Connolly, H. Mashimo, J.G. Fujimoto, "Ultrahigh Resolution and 3D Optical Coherence Tomography Ex Vivo Imaging of the Large and Small Intestine," Gastrointestinal Endoscopy, 62, 561-574 (2005).

Y. Chen, X. Intes, B. Chance, "Development of High Sensitivity Near-Infrared (NIR) Fluorescence Imaging Device for Early Cancer Detection," Biomedical Instrumentation and Technology, 39, 75-85 (2005).  (Outstanding Instrumentation Research Paper)

P.R. Herz, Y. Chen, A. Aguirre, K. Schneider, P. Hsiung, K. Madden, J. Schmitt, J. Goodnow, C. Petersen, J.G. Fujimoto, "Micro-Motor Endoscope Catheter for In Vivo Ultrahigh Resolution Optical Coherence Tomography," Optics Letters, 29, 2261-2263 (2004).

P.R. Herz, Y. Chen, A. Aguirre, J.G. Fujimoto, H. Mashimo, J. Schmitt, A. Koski, J. Goodnow, C. Petersen, "Ultrahigh Resolution Optical Biopsy with Endoscopic Optical Coherence Tomography," Optics Express, 12, 3532-3542 (2004)

Y. Chen, G. Zheng, Z. Zhang, D. Blessington, Q. Liu, X. Intes, L. Zhou, H. Li, M. Zhang, S. Achilefu, B. Chance, "Metabolism Enhanced Tumor Localization by Fluorescence Imaging: In Vivo Animal Studies," Optics Letters, 28, 2070-2072 (2003).

X. Intes, J. Ripoll, Y. Chen, S. Nioka, A.G. Yodh, B. Chance, "In Vivo Continuous Wave Optical Breast Imaging Enhanced by Indocyanine Green," Medical Physics, 30, 1039-1047 (2003).

Y. Chen, D. Tailor, X. Intes, B. Chance, "Correlation between Near-Infrared Spectroscopy and Magnetic Resonance Imaging of Rat Brain Oxygenation Modulation," Physics in Medicine and Biology, 48, 417-427 (2003).

Y. Chen, C. Mu, X. Intes, B. Chance, "Adaptive Calibration for Object Localization in Turbid Media with Interfering Diffuse Photon Density Waves," Applied Optics, 41, 7325-7333 (2002).

X. Intes, Y. Chen, X. Li, B. Chance, "Detection Limit Enhancement of Florescent Heterogeneities in Turbid Media by Dual Interfering Excitation," Applied Optics, 41, 3999-4007 (2002).

Y. Chen, C. Mu, X. Intes, B. Chance, "Signal-to-Noise Analysis for Detection Sensitivity of Small Absorbing Heterogeneity in Turbid Media with Single-source and Dual-Interfering-Source," Optics Express, 9, 212-224 (2001).

Y. Chen, S. Zhou, C. Xie, S. Nioka, M. Papadopoulos, E. Anday, B. Chance, "Preliminary Evaluation of Dual Wavelength Phased Array Imaging on Neonatal Brain Function," Journal of Biomedical Optics, 5, 194-200 (2000).

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