Event

Special Seminar: Zhongping Chen

Tuesday, September 16, 2014
11:00 a.m.-12:00 p.m.
Pepco Room (1105), Jeong H. Kim Engineering Building
Associate Professor Yu Chen
yuchen@umd.edu

Prof. Zhongping Chen
Department of Biomedical Engineering
Beckman Laser Institute
The Edwards Life Sciences Center for Advanced Cardiovascular Technology
University of California, Irvine, Irvine, CA

Seventeen Years of Doppler Optical Coherence Tomography

Optical coherence tomography (OCT) is one of the fastest growing areas of biomedical optics with many potential clinical applications.  The recent development of Fourier domain OCT has significantly increased imaging speed and sensitivity, and has enabled real-time 3-D imaging. Many of the functional extensions of OCT technology that were developed in the last decade, such as Doppler OCT, have started to generate clinically important information in clinical studies. 

Noninvasive techniques for imaging in vivo blood flow are of great value to biomedical research and clinical diagnostics where many diseases have a vascular etiology or component.  In ophthalmology, many ophthalmic diseases may involve disturbances in ocular blood flow, including diabetic retinopathy, low tension glaucoma, anterior ischemic optic neuritis, and macular degeneration.  For example, in diabetic retinopathy, retinal blood flow is reduced and the normal autoregulatory capacity is deficient.  Ocular hemodynamics is altered in patients with glaucoma, and severe loss of visual function has been associated with reduced macular blood flow.  Simultaneous imaging of tissue structure and blood flow could provide critical information for early diagnosis of ocular diseases.  

In this presentation, I will review the advances in Doppler OCT over the last seventeen years. The recent applications of Doppler OCT for quantifying the flow, imaging the vasculature, evaluating the vibration organ, and optical coherence elastography will be discussed.  
 

About the Speaker

Dr. Zhongping Chen is a Professor of Biomedical Engineering and Director of the OCT Laboratory at the University of California, Irvine.  He is a Co-founder and Chairman of OCT Medical Imaging Inc. Dr. Chen received his B.S. degree in Applied Physics from Shanghai Jiao Tong University in 1982, his M. S. degree in Electrical Engineering in 1987, and his Ph.D. degree in Applied Physics from Cornell University in 1993. 

Dr. Chen's research interests encompass the areas of biomedical photonics, microfabrication, biomaterials and biosensors. His research group has pioneered the development of functional optical coherence tomography, which simultaneously provides high resolution 3-D images of tissue structure, blood flow, and birefringence.  These functional extensions of OCT offer contrast enhancements and provide mapping of many clinically important parameters.  In addition, his group has developed a number of endoscopic and intravascular rotational and linear 2-D probes for OCT and MPM imaging and translated this technology to clinical applications through collaboration with clinicians.  He has led numerous major research projects funded by NIH, NSF, DOD, and DARPA, including several interdisciplinary research projects such as the NIH Biomedical Research Partnership (BRP) grant and NSF Biophotonics Partnership Initiative grant. He has published more than 190 peer-reviewed papers and review articles and holds a number of patents in the fields of biomaterials, biosensors, and biomedical imaging. 

Dr. Chen is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE), a Fellow of SPIE, and a Fellow of the Optical Society of America.