Event
Bioengineering Seminar Series: Jordan Green
Friday, May 9, 2014
9:00 a.m.-10:00 a.m.
Pepco Room (1105), Jeong H. Kim Engineering Building
Professor Christopher Jewell
cmjewell@umd.edu
Jordan Green
Assistant Professor
Department of Biomedical Engineering
Johns Hopkins University
Bioengineered Polymeric Particles for Gene Therapy and for Immunotherapy
The Green lab uses biodegradable polymers to construct nanoparticles that are safe and effective for intracellular gene delivery and biomimetic particles that act as artificial antigen presenting cells. For intracellular delivery, the effect of differential polymer structure on the delivery of nucleic acids of different structures and sizes will be elucidated. Biomaterial structure, and in particular polymer end-group, can determine cell-type specificity of nanoparticles in a range of cell types, including cancer cells vs. healthy cells. Biomaterial degradation mechanism, and in particular bioreducible disulfide linkages, can enable environmentally triggered release and high siRNA-mediated knockdown. The role of particle size and shape in constructing artificial antigen presenting cells and how these biomimetic particles can be used in cancer immunotherapy will be also be presented.
ABOUT THE SPEAKER
Dr. Jordan J. Green is an associate professor of Biomedical Engineering, Ophthalmology, and Neurosurgery at the Johns Hopkins University School of Medicine. He is also a member of the Institute for Nanobiotechnology and the Translational Tissue Engineering Center at JHU. Dr. Green received his B.S. in biomedical engineering and chemical engineering from Carnegie Mellon University in 2003 and completed his Ph.D. in biological engineering from the Massachusetts Institute of Technology in 2007. Subsequently, Dr. Green was a postdoctoral associate at MIT in Institute Professor Robert Langer’s lab from 2007-2008 and was also a biotechnology consultant. He is the CEO and a co-founder of the startup company AsclepiX Therapeutics and on the Scientific Advisory Board of the biotechnology company NexImmune. His work has resulted in 52 peer-reviewed papers, 12 patents/patent applications, and he has received numerous awards including the Maryland Outstanding Young Engineer Award, the Carnegie Mellon University Recent Alumni Award, and the Biomedical Engineering Society Rita Schaffer Award. Dr. Green’s main research interests are in developing biomaterials and nanobiotechnology to meet challenges in regenerative medicine, ophthalmology, and cancer.
