Event

Bioengineering Seminar Series: Joan-Emma Shea

Friday, February 15, 2013
11:00 a.m.
Pepco Room, Jeong H. Kim Engineering Building
Professor Silvina Matysiak
matysiak@umd.edu

Effect of Surfaces on Protein Folding and Assembly

Joan-Emma Shea
Professor
Department of Chemistry and Biochemistry
University of California Santa Barbara

The folding of a protein to its native state is critical for the correct functioning of the cell. When proteins do not fold correctly, they can self-assembly into large aggregate structures that can deposit on organs in the body. A number of diseases, including Type II Diabetes and Alzheimer’s Disease, are associated with this process. Under cellular conditions, proteins encounter a variety of surfaces, from chaperones to membranes, that can alter folding pathways. In this talk, I will present atomistic and coarse-grained simulations to probe the effect of surfaces on folding and aggregation.

Audience: Graduate  Faculty  Post-Docs